Database of African Theses and Dissertations including Research (DATAD-R)

Association between birth outcomes and aflatoxin B1 biomarker blood levels in pregnant women in Kumasi, Ghana

Show simple item record

dc.creator Williams, Jonathan H.
dc.creator Wang, Jia-Sheng
dc.creator Ellis, William Otoo
dc.creator Wilson, Craig
dc.creator Person, Sharina D.
dc.creator Funkhouser, Ellen
dc.creator Yatich, Nelly
dc.creator Ehiri, John E.
dc.creator Jolly, Pauline E.
dc.creator Shuaib, Faisal M. B.
dc.date 2016-11-08T10:39:34Z
dc.date 2016-11-08T10:39:34Z
dc.date 2010-02
dc.date.accessioned 2018-06-24T00:28:12Z
dc.date.available 2018-06-24T00:28:12Z
dc.identifier Tropical Medicine and International Health doi:10.1111/j.1365-3156.2009.02435.x volume 15 no 2 pp 160–167 february 2010
dc.identifier http://hdl.handle.net/123456789/9645
dc.identifier.uri http://hdl.handle.net/123456789/6545
dc.description To investigate the association between birth outcomes and blood levels of aflatoxin B1 (AFB1)-lysine adduct in pregnant women in Kumasi, Ghana. A cross-sectional study of 785 pregnant women attending antenatal clinic was conducted. Aflatoxin B1 (AFB1)-lysine adduct levels were determined by high performance liquid chromatography (HPLC) on blood taken after delivery. The birth outcomes considered were small for gestation age, low birthweight, preterm delivery and stillbirth. Participants were divided into quartiles based on the distribution of aflatoxin B1-lysine adducts in pg ⁄mg albumin (‘low’: £2.67, ‘moderate’: >2.67 to £4.97, ‘high’: >4.97 to £11.34, ‘very high’: >11.34). Statistical analysis involved models that included sociodemographic variables and other potential confounders. results The average AFB1-lysine adduct level in maternal serum was 10.9 ± 19.00 pg ⁄mg albumin (range = 0.44–268.73 pg ⁄ mg). After adjusting for socio-demographic variables and potential confounding factors, participants in the highest AFB1-lysine quartile with ‘very high’ AFB1-lysine level (>11.34 pg ⁄ mg) were more likely to have low birthweight babies (OR, 2.09; 95% CI, 1.19–3.68), and showed a trend of increasing risk for low birthweight (Ptrend = 0.007) compared to participants in the lowest quartile. This study adds to the growing body of evidence that aflatoxins may increase the risk of adverse birth outcomes. The findings have implications for targeted nutritional education of pregnant women in areas with high levels of aflatoxin contamination of foods
dc.description This Article was published by Tropical Medicine and International Health doi:10.1111/j.1365-3156.2009.02435.x volume 15 no 2 pp 160–167 february 2010
dc.description KNUST
dc.language en
dc.publisher Tropical Medicine and International Health
dc.subject Kumasi
dc.subject pregnancy
dc.subject birth outcomes
dc.subject aflatoxins
dc.title Association between birth outcomes and aflatoxin B1 biomarker blood levels in pregnant women in Kumasi, Ghana
dc.type Article


Files in this item

Files Size Format View
Association bet ... es and aflatoxin B1....pdf 86.25Kb application/pdf View/Open

This item appears in the following Collection(s)

Show simple item record

Search DATAD-R


Browse

My Account