Nigerian propolis: chemical composition, antioxidant activity and α-amylase and α-glucosidase inhibition
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Date
2019-11-08
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor and Francis
Abstract
Propolis is an attractive natural ingredient to design health products due to its pharmacological effects. Our chemical investigation of a polar extract of Nigerian propolis (NP) led the isolation and identification of five isoflavonoids (1-4, 6), one diarylpropane (5) and one prenylated flavanone (7) by the combination of chromatographic and spectroscopic techniques. Compounds 1, 4 and 7 were found to be the main markers in NP (8.0, 5.0 and 4.0 mg/g of dry extract, respectively). Moreover, NP and its phenolic constituents exhibited in vitro free radical scavenging activity together with a promising antidiabetic effect against α-amylase and α-glucosidase enzymes. Finally, NP showed also a moderate inhibition of Helicobacter pylori growth. These results suggested that NP could be a good candidate in nutraceuticals and food products.
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Keywords
α-amylase and α-glucosidase enzymes, Nigerian propolis, polyphenols free-radical scavenging activity, Helicobacter pylori, Université de Ouaga, ACEDHARS, ACE: Drug Research, Herbal Medicine Development and Regulatory Science