Clock genes and environmental cues coordinate Anopheles pheromone synthesis, swarming, and mating

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dc.contributor.authorWang, Guandong
dc.contributor.authorVega-Rodríguez, Joel
dc.contributor.authorDiabate, Abdoulaye
dc.date.accessioned2023-06-10T10:44:10Z
dc.date.available2023-06-10T10:44:10Z
dc.date.issued2021-01-22
dc.description.abstractAnopheles mating is initiated by the swarming of males at dusk followed by females flying into the swarm. Here, we show that mosquito swarming and mating are coordinately guided by clock genes, light, and temperature. Transcriptome analysis shows up-regulation of the clock genes period (per) and timeless (tim) in the head of field-caught swarming Anopheles coluzzii males. Knockdown of per and tim expression affects Anopheles gambiae s.s. and Anopheles stephensi male mating in the laboratory, and it reduces male An. coluzzii swarming and mating under semifield conditions. Light and temperature affect mosquito mating, possibly by modulating per and/or tim expression. Moreover, the desaturase gene desat1 is up-regulated and rhythmically expressed in the heads of swarming males and regulates the production of cuticular hydrocarbons, including heptacosane, which stimulates mating activityen_US
dc.description.sponsorshipACE: Bio-technological Innovation for the Elimination of Vector- Borne Diseasesen_US
dc.identifier.urihttp://hdl.handle.net/123456789/1943
dc.language.isoenen_US
dc.publisherScienceen_US
dc.relation.ispartofseriesScience;371
dc.subjectAnophelesen_US
dc.subjectmatingen_US
dc.subjectJingnan Liuen_US
dc.subjectChunlai Cuien_US
dc.subjectCharles Nignanen_US
dc.subjectBurkina Fasoen_US
dc.subjectUniversité Nazi Bonien_US
dc.subjectCEA-ITECH_MTVen_US
dc.subjectACE: Bio-technological Innovation for the Elimination of Vector- Borne Diseasesen_US
dc.titleClock genes and environmental cues coordinate Anopheles pheromone synthesis, swarming, and matingen_US
dc.typeArticleen_US
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