Plasmodium infection induces cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein

Lapidus, Sarah; Liu, Feimei; Casanovas-Massana, Arnau

Plasmodium infection induces cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein

Files

Plasmodium infection.pdf (5.33 MB)

Date

2021

Authors

Lapidus, Sarah

Liu, Feimei

Casanovas-Massana, Arnau

Publisher

medRxiv

Abstract

Individuals with acute malaria infection generated high levels of antibodies that cross-react with the SARS-CoV-2 Spike protein. Cross-reactive antibodies specifically recognized the sialic acid moiety on N-linked glycans of the Spike protein and do not neutralize in vitro SARS-CoV-2. Sero-surveillance is critical for monitoring and projecting disease burden and risk during the pandemic; however, routine use of Spike protein-based assays may overestimate SARS-CoV-2 exposure and population-level immunity in malaria-endemic countries

Keywords

Yile Da, John D. Huc, Carolina Lucas, Plasmodium, ACE: Bio-technological Innovation for the Elimination of Vector- Borne Diseases, Université Nazi Boni, CEA-ITECH_MTV

URI

http://hdl.handle.net/123456789/1936

Collections

Health

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