A Toll-like receptor 2 genetic variant modulates

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dc.contributor.authorTozatto-Maio, Karina
dc.contributor.authorGirot, Robert
dc.contributor.authorLy, Indou D.
dc.contributor.authorRocha, Vanderson
dc.contributor.authorPinto, Ana C. Silva
dc.contributor.authorDiagne, Ibrahima
dc.contributor.authorBenzerara, Yahia
dc.contributor.authorDinardo, Carla L.
dc.contributor.authorKashima, Simone
dc.contributor.authorLeston- Araujo, Itauá
dc.date.accessioned2022-05-17T11:39:38Z
dc.date.available2022-05-17T11:39:38Z
dc.date.issued2019-03-25
dc.description.abstractDespite adequate immunization and penicillin prophylaxis, bacterial infections remain a leading cause of morbidity and mortality in patients with sickle cell disease (SCD). Besides hyposplenism, inflammatory and genetic factors might modulate their susceptibility to bacterial infections. We performed a candidate gene association of single nucleotide polymorphisms (SNPs) located in Toll-like receptor (TLR) genes, encoding prominent molecules for innate immune responses, with the occurrence of bacterial infections in patients with SCD. A cohort followed in centres in Brazil, France and Senegal (n = 430) was divided in two groups: patients who presented at least one episode of bacterial infection (n = 235) and patients who never had bacterial infections (n = 195). There were no differences in gender or age distribution among the groups. The frequency of the TLR2 rs4696480 TA genotype was significantly lower in the infected group (50% vs. 67%, odds ratio [OR] = 0·50, 95% confidence interval [CI] 0·34–0·75, P < 0·001), and the TT genotype was significantly higher in the infected group (15% vs. 5%, OR = 3·18, 95% CI 1·53–6·61, P < 0·001). Previous reports demonstrated higher secretion of inflammatory factors in cells from AA individuals, lower occurrence and severity of immune diseases in T carriers. The rs4696480 TA genotype might stand between deleterious effects of over inflammatory response (AA genotype) and inefficient responses (TT genotype) to infectious agents in SCD settings.en_US
dc.description.sponsorshipThe Centre Scientifique de Monaco and the Brazilian Coordination for the Improvement of Higher Education Personnel (CAPES). World Bank.en_US
dc.identifier.citationTozatto-Maio et al. (2019) A Toll-like receptor 2 genetic variant modulates occurrence of bacterial infections in patients with sickle cell disease. British Journal of Haematology, Volume 185, Issue 5 p. 918-924. https://doi/10.1111/bjh.15875en_US
dc.identifier.urihttp://hdl.handle.net/123456789/1443
dc.language.isoenen_US
dc.publisherBritish Journal of Haematologyen_US
dc.relation.ispartofserieshttps://onlinelibrary.wiley.com/doi/10.1111/bjh.15875;7
dc.subjectToll-like receptoren_US
dc.subjectbacterial infectionsen_US
dc.subjectsickle cell diseaseen_US
dc.subjectimmunizationen_US
dc.titleA Toll-like receptor 2 genetic variant modulatesen_US
dc.typeArticleen_US
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