Browsing by Author "Sow, Doudou"

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    Mycetoma epidemiology, diagnosis management, andoutcome in three hospital centres in Senegal from 2008 to2018
    (Sow et al., 2020-04-24) Sow, Doudou; Ndiaye, Maodo; Sarr, Lamine
    Mycetoma is a neglected tropical disease caused by various actinomycetes or fungi. The disease is characterized by the formationof tumor like-swellings and grains. Senegal is an endemic country where mycetoma cases are under-or misdiagnosed due to thelack of capacities and knowledge among health workers and the community; and where the management of eumycetoma,burdened by a high amputation rate, is currently inadequate. This study aimed to update data on the epidemiology of mycetomacases diagnosed in three hospital centres in Senegal over a 10 years-period. A total of 193 patients, diagnosed from 2008 to 2018,were included in the study. The most frequent presentation was eumycetoma (47.2%); followed by actinomycetoma (36.8%); itremained undetermined in 16.1% of the patients. The mean age was 38.3 years (68.4% of the patients were between 15 and 45years-old); the male: female ratio was a 2.94; and most were farmers. One hundred fifty-six (80.8%) patients had usedphytotherapy before attending the hospital. Mycetoma was mainly located to the lower limbs (91.2%). Grains were observed in 85%of the patients; including white (25.6%) and yellow (4.3%) grains. The etiological diagnosis was complex, resulting in negative directmicroscopy, culture and/or histopathology findings, which explains that 16.1% remained uncharacterized. In most of cases,actinomycetoma were treated with a combination of cotrimoxazole, amoxicillin/clavulanic acid, and streptomycin; whereaseumycetoma cases were treated with terbinafine. The surgery was done in 100 (51.8%) of the patients including 9 inactinomycetoma, 78 in eumycetoma and 13 in undetermined form. The high number of uncharacterized mycetoma in this study, thedelay in attending a qualified health-care facility, and the lack of available adequate antifungal drug, point out the need tostrengthen mycetoma management capacities in Senegal.
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    A Study of Trichomonas vaginalis Infection and Correlates
    (Journal of Parasitology Research, 2019-04-01) Tine, Roger C.; Sylla, Khadime; Ka, Rougyatou; Dia, Lamine; Sow, Doudou; Lelo, Souleye; Diallo, Khardiata; Faye, Babacar; Dieng, Thérèse; Ndour, Cheikh T.; Sow, Ahmet Y.
    Introduction Trichomoniasis is nowadays the most prevalent non-viral sexually transmitted infection in the world. In Senegal, the epidemiology of trichomoniasis is not well known. The current study aimed at assessing the prevalence and factors associated with T. vaginalis infection among women with vaginal discharge. Methods A retrospective analysis of laboratory records from patients referred at the Fann Teaching Hospital in Dakar, Senegal, for vaginal discharge was carried out. The study covered the period from 2006 to 2011. For each participating woman, a vaginal swab was collected and a wet mount smear performed immediately. Optic microscopic examination with 40x magnification was done to detect T. vaginalis and assess biological modifications such as presence of epithelial cells, white blood cells, and red blood cells. A gram stained smear was also performed and examined under oil immersion (100x magnification) to assess the vaginal flora. Results Overall, 3893 women were enrolled with a mean age at 31.2 ± 10 years. The prevalence of Trichomoniasis represented 4.8%, 95%CI(3.1-5.7) and it was lower among women less than 30 years (4.1%), while divorced women more likely to be infected compared to married and single women (aOR:2.1, 95%CI (1.2-3.7)). Trichomoniasis was associated with abnormal vaginal flora such as type III (aOR:2.6, 95%CI(1.5-4.4)) and type IV (aOR:3.3, 95%CI(2.1-5.3)). In addition, patients with erythrocytes excretion were more likely to be infected by T. vaginalis (aOR:2.8, 95%CI(1.9-3.9). Conclusion Trichomonas vaginalis remains prevalent among sexually active women. Strategies aiming at improving disease awareness in these high-risk groups are needed to improve trichomoniasis prevention but extensive epidemiological data are still needed for a better understanding of the disease transmission dynamic.