Toxicity studies on the leaves of senna alata, a medicinal plant from Burkina Fas, in mice and rats
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Date
2020-11
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Abstract
The aim of the work is to study the acute and subacute toxicity of the
aqueous extract of the leaves of Senna alata (ED-SA). Extracts doses
of 500, 1000 and 2000 mg/kg of body weight (bw) were administered
to the mice for acute toxicity study. The administration volume was 1
ml/100g. A limit test has been carried out to determine the DL50. For
subacute toxicity, rats received Senna alata extracts orally for 28 days.
The first group to constitute the control received distilled water
(solvent for diluting the extracts). Groups 2, 3 and 4 received extracts
of S. alata at the respective doses of 500, 1000 and 2000 mg/kg of
body weight; satellite groups 5 and 6 received, respectively, distilled
water (satellite control) and extract at the maximum dose of 2000
mg/kg (satellite). The satellite groups were observed 14 days after
stopping treatment to assess reversibility to toxicity. The collected
serum was used for biochemical assays (ALAT, ASAT, creatinine, total cholesterol, and
triglycerides). Plasma has been used to assess the effects of the extract on hematological
parameters such as blood cells, red blood cells, hematocrit, hemoglobin. The acute toxicity
assessment of the aqueous extract of Senna alata has shown that the lethal dose 50 (DL50) is
greater than 2000 mg/kg, suggesting that the extract would be practically non-toxic at this
dose. In subacute toxicity, no major lesion was observed after histological analysis of the
liver and kidneys. These results suggest that the aqueous extract of Senna alata does not
affect liver and kidney. In conclusion, this study shows that ED-SA is of low toxicity.
Description
World Journal of Pharmacy and Pharmaceutical Sciences, Volume 9, Issue 11, 85-95 │ ISO 9001:2015 Certified Journal
Keywords
Acute toxicity, subacute toxicity, rats, mice, Senna alata, Sawadogo Touwindséda Aimée, Sawadogo Paténéma, Bayala Balé, CEFORGRIS, Joseph Ki-Zerbo University and Ouaga II University, Burkina Faso
Citation
TY - JOUR AU - Léonard, Da AU - Youssoufou, Ouédraogo AU - Abel, Somé AU - Aimée, Sawadogo AU - Paténéma, Sawadogo AU - Bayala, Balé AU - Koudougou, Norbert AU - Bp AU - Faso, Burkina PY - 2020/11/01 SP - 85 EP - 95 T1 - TOXICITY STUDIES ON THE LEAVES OF SENNA ALATA, A MEDICINAL PLANT FROM BURKINA FASO, IN MICE AND RATS VL - 9 DO - 10.20959/wjpps202011-17621 JO - WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES ER -