Influence of Oxidative Stress Biomarkers and Genetic Polymorphisms on the Clinical Severity of Hydroxyurea-Free Senegalese Children with Sickle Cell Anemia

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dc.contributor.authorTall, Fatou Gueye
dc.contributor.authorMartin, Cyril
dc.contributor.authorNdour, El hadji Malick
dc.date.accessioned2023-05-04T20:49:10Z
dc.date.available2023-05-04T20:49:10Z
dc.date.issued2020-09-14
dc.description.abstractOxidative stress would play a role in the pathophysiology of sickle cell anemia (SCA).We tested the impact of common SCA genetic modifiers (alpha-thalassemia, G6PD deficiency, HbF quantitative trait loci; QTL) and pro/antioxidant genes polymorphisms (SOD2 rs4880, XO rs207454,MPO rs2333227) on oxidative stress biomarkers (AOPP, MDA, MPO, XO, MnSOD, CAT, GPx) and clinical severity in 301 Senegalese SCA hydroxyurea-free children at steady-state (median age 9.1 years, sex ratio H/F = 1.3). Plasma oxidative stress biomarkers were compared with those of a control group (AA). CAT activity, AOPP, and MDA levels were higher in SCA than in AA individuals while XO, GPX, and MnSOD activities were lower. The presence of alpha-thalassemia decreased MDA level and MPO activity but no effect of the HbF QTL or G6PD deficiency was observed. SCA children who experienced their first hospitalized complication before 3 years old had higher MnSOD and CAT activities than the other children while those with no hospitalized VOC in the previous 2 years presented higher GPX activity. Age of the first hospitalized complication and AOPP levels were affected by the MPO rs2333227 SNP. Our results suggest that alpha-thalassemia modulates oxidative stress in SCA, presumably because of a reduction in the MPO activityen_US
dc.description.sponsorshipACE: Maternal and Infant Healthen_US
dc.identifier.issn2076-3921
dc.identifier.urihttp://hdl.handle.net/123456789/1711
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofseriesAntioxidants;2020, 9, 863
dc.subjectCamille Faesen_US
dc.subjectIndou Déme Lyen_US
dc.subjectVincent Pialouxen_US
dc.subjectUniversité Cheikh Anta Diopen_US
dc.subjectACE: Maternal and Infant Healthen_US
dc.subjectsickle cell anemiaen_US
dc.subjecthydroxyurea-freeen_US
dc.subjectalpha-thalassemiaen_US
dc.subjectHbF QTLen_US
dc.subjectG6PD deficiencyen_US
dc.subjectclinical severityen_US
dc.subjectoxidative stress parametersen_US
dc.subjectoxidative stress polymorphismsen_US
dc.subjectACE: Maternal and Infant Healthen_US
dc.titleInfluence of Oxidative Stress Biomarkers and Genetic Polymorphisms on the Clinical Severity of Hydroxyurea-Free Senegalese Children with Sickle Cell Anemiaen_US
dc.typeArticleen_US
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