Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications

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dc.contributor.authorAbdulai, Ibrahim Luru
dc.contributor.authorKwofie, Samuel Kojo
dc.contributor.authorGbewonyo, Winfred Seth
dc.date.accessioned2023-04-22T14:12:58Z
dc.date.available2023-04-22T14:12:58Z
dc.date.issued2021-04-12
dc.description.abstractBackground. Till date, there is no known antidote to cure diabetes mellitus despite the discovery and development of diverse pharmacotherapeutic agents many years ago. Technological advancement in natural product chemistry has led to the isolation of analogs of vitexin and isovitexin found in diverse bioresources. 'ese compounds have been extensively studied to explore their pharmacological relevance in diabetes mellitus. Aim of the Study. 'e present review was to compile results from in vitro and in vivo studies performed with vitexin and isovitexin derivatives relating to diabetes mellitus and its complications. A systematic online literature query was executed to collect all relevant articles published up to March 2020. Results. In this piece, we have collected data and presented it in a one-stop document to support the multitargeted mechanistic actions of vitexin and isovitexin in controlling diabetes mellitus and its complications. Conclusion. Data collected hint that vitexin and isovitexin work by targeting diverse pathophysiological and metabolic pathways and molecular drug points involved in the clinical manifestations of diabetes mellitus. 'is is expected to provide a deeper understanding of its actions and also serve as a catapult for clinical trials and application research.en_US
dc.description.sponsorshipACE: Cell Biology of Infectious and Non-Communicable Diseasesen_US
dc.identifier.citationdoi: 10.1155/2021/6641128en_US
dc.identifier.issn2356-6140
dc.identifier.issn1537-744X
dc.identifier.urihttp://hdl.handle.net/123456789/1512
dc.language.isoenen_US
dc.publisherHindawien_US
dc.relation.ispartofseriesThe Scientific World Journal;Volume 2021
dc.subjectWACCBIPen_US
dc.subjectVitexinen_US
dc.subjectIsovitexinen_US
dc.subjectDiabetes mellitusen_US
dc.subjectDaniel Boisonen_US
dc.subjectJoshua Buer Puplampuen_US
dc.subjectMichael Buenor Adinorteyen_US
dc.titleMultitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complicationsen_US
dc.typeArticleen_US
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