Ex Vivo Plasmodium malariae Culture Method for Antimalarial Drugs Screen in the Field

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dc.contributor.authorDembele, Laurent
dc.contributor.authorDiallo, Nouhoum
dc.contributor.authorSogore, Fanta
dc.date.accessioned2023-04-22T14:17:17Z
dc.date.available2023-04-22T14:17:17Z
dc.date.issued2021-10-28
dc.description.abstractIn vitro and ex vivo cultivation of Plasmodium (P) falciparum has facilitated active research into the malaria parasite toward the quest for basic knowledge and the discovery of effective drug treatments. Such a drug discovery program is currently difficult for P. malariae simply because of the absence of in vitro and ex vivo cultivation system for its asexual blood stages supporting antimalarial evaluation. Despite availability of artemisinin combination therapies effective on P. falciparum, P. malariae is being increasingly detected in malaria endemic countries. P. malariae is responsible for chronic infections and is associated with a high burden of anemia and morbidity. Here, we optimized and adapted ex vivo conditions under which P. malariae can be cultured and used for screening antimalarial drugs. Subsequently, this enabled us to test compounds such as artemether, chloroquine, lumefantrine, and quinine for ex vivo antimalarial activity against P. malariae.en_US
dc.description.sponsorshipACE: Cell Biology of Infectious and Non-Communicable Diseasesen_US
dc.identifier.citationhttps://doi.org/10.1021/acsinfecdis.1c00262en_US
dc.identifier.issn2373-8227
dc.identifier.urihttps://datad.aau.org/handle/123456789/1526
dc.language.isoenen_US
dc.publisherACS Publicationsen_US
dc.relation.ispartofseriesACS Infect Dis;2021, 7, 11
dc.subjectAnatomyen_US
dc.subjectAntimicrobial agentsen_US
dc.subjectGeneticsen_US
dc.subjectInfectious diseasesen_US
dc.subjectParasitesen_US
dc.subjectBintou Diarraen_US
dc.subjectFatoumata I. Ballo,en_US
dc.subjectAmadou Daouen_US
dc.titleEx Vivo Plasmodium malariae Culture Method for Antimalarial Drugs Screen in the Fielden_US
dc.typeArticleen_US
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