The Search for Putative Hits in Combating Leishmaniasis: The Contributions of Natural Products Over the Last Decade

Simple item page
dc.contributor.authorSakyi, Patrick O
dc.contributor.authorAmewu, Richard K.
dc.contributor.authorDevine, Robert N. O. A.
dc.date.accessioned2023-04-22T10:38:55Z
dc.date.available2023-04-22T10:38:55Z
dc.date.issued2021-02-11
dc.description.abstractDespite advancements in the areas of omics and chemoinformatics, potent novel biotherapeutic molecules with new modes of actions are needed for leishmaniasis. The socioeconomic burden of leishmaniasis remains alarming in endemic regions. Currently, reports from existing endemic areas such as Nepal, Iran, Brazil, India, Sudan and Afghanistan, as well as newly affected countries such as Peru, Bolivia and Somalia indicate concerns of chemoresistance to the classical antimonial treatment. As a result, effective antileishmanial agents which are safe and affordable are urgently needed. Natural products from both fora and fauna have contributed immensely to chemotherapeutics and serve as vital sources of new chemical agents. This review focuses on a systematic cross-sectional view of all characterized anti-leishmanial compounds from natural sources over the last decade. Furthermore, IC50/EC50, cytotoxicity and suggested mechanisms of action of some of these natural products are provided. The natural product classification includes alkaloids, terpenes, terpenoids, and phenolics. The plethora of reported mechanisms involve calcium channel inhibition, immunomodulation and apoptosis. Making available enriched data pertaining to bioactivity and mechanisms of natural products complement current efforts geared towards unraveling potent leishmanicides of therapeutic relevanceen_US
dc.description.sponsorshipACE: Cell Biology of Infectious and Non-Communicable Diseasesen_US
dc.identifier.citationhttps://doi.org/10.1007/s13659-021-00311-2en_US
dc.identifier.issn2192-2195
dc.identifier.issn2192-2209
dc.identifier.urihttps://datad.aau.org/handle/123456789/1504
dc.language.isoenen_US
dc.relation.ispartofseriesNatural Products and Bioprospecting;11
dc.subjectWACCBIPen_US
dc.subjectPhenotypic screeningen_US
dc.subjectLeishmaniasisen_US
dc.subjectCytotoxicityen_US
dc.subjectNatural productsen_US
dc.subjectChemoinformaticsen_US
dc.subjectChemotherapeuticsen_US
dc.subjectEmahi Ismailaen_US
dc.subjectWhelton A. Milleren_US
dc.subjectSamuel K. Kwofeen_US
dc.subjectUniversity of Ghanaen_US
dc.titleThe Search for Putative Hits in Combating Leishmaniasis: The Contributions of Natural Products Over the Last Decadeen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
The Search for Putative Hits.pdf
Size:
1.81 MB
Format:
Adobe Portable Document Format
Description:
Main article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Health