Hybridized Zoonotic Schistosoma Infections Result in Hybridized Morbidity Profiles: A Clinical Morbidity Study amongst Co-Infected Human Populations of Senegal

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dc.contributor.authorFall, Cheikh B.
dc.contributor.authorLambert, Sébastien
dc.contributor.authorLéger, Elsa
dc.date.accessioned2023-06-12T16:29:57Z
dc.date.available2023-06-12T16:29:57Z
dc.date.issued2021-08-20
dc.descriptionMicroorganisms 2021, 9, 1776en_US
dc.description.abstractHybridization of infectious agents is a major emerging public and veterinary health concern at the interface of evolution, epidemiology, and control. Whilst evidence of the extent of hybridization amongst parasites is increasing, their impact on morbidity remains largely unknown. This may be predicted to be particularly pertinent where parasites of animals with contrasting pathogenicity viably hybridize with human parasites. Recent research has revealed that viable zoonotic hybrids between human urogenital Schistosoma haematobium with intestinal Schistosoma species of livestock, notably Schistosoma bovis, can be highly prevalent across Africa and beyond. Examining human populations in Senegal, we found increased hepatic but decreased urogenital morbidity, and reduced improvement following treatment with praziquantel, in those infected with zoonotic hybrids compared to non-hybrids. Our results have implications for effective monitoring and evaluation of control programmes, and demonstrate for the first time the potential impact of parasite hybridizations on host morbidity.en_US
dc.description.sponsorshipACE : Environment and Health, CEA-AGIRen_US
dc.identifier.citationFall, C. B., Lambert, S., Léger, E., Yasenev, L., Garba, A. D., Diop, S. D., ... & Webster, J. P. (2021). Hybridized zoonotic Schistosoma infections result in hybridized morbidity profiles: A clinical morbidity study amongst co-infected human populations of Senegal. Microorganisms, 9(8), 1776.en_US
dc.identifier.urihttps://doi.org/10.3390/ microorganisms9081776
dc.identifier.urihttp://hdl.handle.net/123456789/1999
dc.language.isoenen_US
dc.publisherMDPI (Multidisciplinary Digital Publishing Institute)en_US
dc.subjecthybridizationen_US
dc.subjectschistosomiasisen_US
dc.subjectmorbidityen_US
dc.subjectultrasonographyen_US
dc.subjectdisease controlen_US
dc.subjectone healthen_US
dc.subjectCEA-AGIRen_US
dc.subjectUniversité Cheikh Anta Diopen_US
dc.subjectSénégalen_US
dc.subjectLucy Yaseneven_US
dc.subjectAmadou Djirmay Garbaen_US
dc.subjectSamba D. Diopen_US
dc.subjectAnna Borlaseen_US
dc.subjectStefano Catalanoen_US
dc.subjectBabacar Fayeen_US
dc.subjectMartin Walkeren_US
dc.subjectMariama Seneen_US
dc.subjectJoanne P. Websteren_US
dc.titleHybridized Zoonotic Schistosoma Infections Result in Hybridized Morbidity Profiles: A Clinical Morbidity Study amongst Co-Infected Human Populations of Senegalen_US
dc.typeArticleen_US
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