Vitamin D: Possible Therapeutic Roles in Hepatocellular Carcinoma

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dc.contributor.authorAdelani, Isaacson B
dc.contributor.authorRotimi, Oluwakemi A.
dc.contributor.authorMaduagwu, Emmanuel N.
dc.contributor.authorRotimi, Solomon O.
dc.date.accessioned2023-08-31T16:20:17Z
dc.date.available2023-08-31T16:20:17Z
dc.date.issued2021-05-25
dc.description.abstractHepatocellular carcinoma (HCC) is a unique type of liver cancer instigated by underlying liver diseases. Pre-clinical evidence suggests that HCC progression, like other cancers, could be aided by vitamin D deficiency. Vitamin D is a lipid-soluble hormone usually obtained through sunlight. Vitamin D elucidates its biological responses by binding the vitamin D receptor; thus, promoting skeletal mineralization, and maintain calcium homeostasis. Other reported Vitamin D functions include specific roles in proliferation, angiogenesis, apoptosis, inflammation, and cell differentiation. This review highlighted studies on vitamin D’s functional roles in HCC and discussed the specific therapeutic targets from various in vivo, in vitro and clinical studies over the years. Furthermore, it described recent advancements in vitamin D’s anticancer effects and its metabolizing enzymes’ roles in HCC development. In summary, the review elucidated specific vitamin D-associated target genes that play critical functions in the inhibition of tumorigenesis through inflammation, oxidative stress, invasion, and apoptosis in HCC progression.en_US
dc.description.sponsorshipACE: Applied Informatics and Communicationen_US
dc.identifier.issn2234-943X
dc.identifier.urihttp://hdl.handle.net/123456789/2114
dc.language.isoenen_US
dc.publisherFront. Oncolen_US
dc.relation.ispartofseriesFront. Onco;11
dc.subjectvitamin Den_US
dc.subjecttherapeuticen_US
dc.subjectinflammationen_US
dc.subjectapoptosisen_US
dc.subjectdifferentiationen_US
dc.subjectproliferationen_US
dc.subjecthepatocellular carcinomen_US
dc.subjectNigeriaen_US
dc.subjectACE: Applied Informatics and Communicationen_US
dc.subjectCovenant Universityen_US
dc.subjectDigital Developmenten_US
dc.titleVitamin D: Possible Therapeutic Roles in Hepatocellular Carcinomaen_US
dc.typeArticleen_US
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