Evaluation of hormonal profile and some stress biomarkers in infertile couples in Abuja, Nigeria

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dc.contributor.authorAbriba, Simon P.
dc.contributor.authorOsadolar, Humphrey B.
dc.date.accessioned2023-06-05T10:37:01Z
dc.date.available2023-06-05T10:37:01Z
dc.date.issued2020-02-29
dc.description.abstractBackground: Infertility is a growing gynecological problem in couples of childbearing age having difficulties bearing children. Couples with infertility are known to present with high levels of stress and psychopathology A cross sectional case control study aimed at evaluating the hormonal profile, some stress biomarkers, sperm analysis in infertile couples was carried out to ascertain their contributions to infertility in couples of child bearing age. Methods: Serum Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), Prolactin, Progesterone, Estrogen (E2), Testosterone, Salivary Cortisol and Salivary Alpha Amylase were evaluated using both competitive and non-competitive Enzyme Linked Immunosorbent Assay (ELISA) techniques; while sperm cells analysis were evaluated using conventional methods, in 164 infertile couples (study) and 100 fertile couples (control) attending fertility clinic in General Hospitals in Abuja, Nigeria. Results: The mean serum Prolactin and Salivary (S) Cortisol in the female were significantly higher (p<0.05) in the study group relative to the control group, while Salivary Alpha Amylase and LH show no significant difference (p>0.05) between the two groups. FSH, Progesterone and E2 in the female were significantly lower in the study group (p<0.05) compared with control group. Testosterone, FSH, Sperm cells count and Sperm activity (%) were significantly lower (p<0.05) in the male study group relative to the control group; while prolactin, S. cortisol and S. amylase were significantly higher (p<0.05) in the male study group relative to the control group. Conclusions: Abnormal hormones values and abnormal sperm quality and quantity are associated with elevated stress biomarkers in couples presenting with infertility. Strong positive correlations exist between hormones and stress biomarker in infertility conditions.en_US
dc.description.sponsorshipACE: Reproductive Health Innovationen_US
dc.identifier.citationAbriba, S. P., & Osadolor, H. B. (2020). Evaluation of hormonal profile and some stress biomarkers in infertile couples in Abuja, Nigeria. International Journal of Research in Medical Sciences, 8(4), 1514–1522. https://doi.org/10.18203/2320-6012.ijrms20201352en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.urihttp://hdl.handle.net/123456789/1903
dc.language.isoenen_US
dc.publisherInternational Journal of Research in Medical Scienceen_US
dc.relation.ispartofseriesInternational Journal of Research in Medical Science;Vol. 8, Issue 4
dc.subjectBiomarkers of Stressen_US
dc.subjectCouples Infertilityen_US
dc.subjectHormonal Profileen_US
dc.subjectSperm Cells Counten_US
dc.subjectACE: Reproductive Health Innovationen_US
dc.subjectCERHIen_US
dc.subjectNigeriaen_US
dc.subjectUniversity of Beninen_US
dc.titleEvaluation of hormonal profile and some stress biomarkers in infertile couples in Abuja, Nigeriaen_US
dc.typeArticleen_US
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