Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2): What Can Africa Learn from Ongoing Research in Epidemiology, Clinical Manifestations, Chemotherapy and Prevention?

dc.contributor.authorSevidzem, Silas Lendzele
dc.contributor.authorKoumba, Aubin Armel
dc.contributor.authorZinga-Koumba, Christophe Roland
dc.descriptionAsian Journal of Medicine and Health, 18(6): 17-27, 2020; Article no.AJMAH.58240en_US
dc.description.abstractThe world is experiencing an outbreak due to the new and mysterious SARS-CoV-2. Information regarding its source and transmission dynamics in different environments as well as medications for its prevention and cure is weak. This review seeks to document on the epidemiology, clinical signs, control, prevention, and present some perspectives for SARS-CoV-2 research in Africa. There are geographical differences in morbidity and mortality rates of this disease all over the world. The scientific community strongly reject claims regarding the fact that the virus has been genetically manipulated, but supports the theory that it has a natural origin from animal host as any other emerging viral disease. Although animals are thought to be the original source of global spill over, person-to-person transmission is well comprehended. Transmission could be enhanced by symptomatic and asymptomatic individuals with high contaminations reported in dense urban environments. Scientific evidences from the Center for Disease Control (CDC) and other publications reported that contaminated surfaces and air could possibly be the underlying mechanism through which SARS-CoV-2 spreads. Cohort studies reveal that children as well as adults could be vulnerable to the disease, but others attribute it to health care workers, some risky habits (drinking and smoking) and comorbid individuals due to their immune suppressed status. There is no drug of choice for SARS-CoV-2, but clinical studies including several antiviral drugs are underway. Similarly, vaccine studies and clinical trial studies are ongoing. Because there is no medication, preventive measures such as Personal Protective Equipments (PPEs), ventilators, sanitation, social distancing, and quarantine are the gears globally used to curb the spread of this virus. The African continent does not have high morbidity and mortality compared to other continents that are highly affected. The following lessons could be learned by Africans from ongoing research: that the SARS-CoV-2 originated from an animal host, individuals could be infected irrespective of their age, sex, race, and origin, there is a broad spectrum of clinical signs and confirmatory diagnosis is required, there is no approved drug of choice, vaccine trials are ongoing and community-based prevention is required, the recommendations put in place by the Government and the WHO to curb the spread of this virus should be strictly followed. From the above lessons, a research project to study the ecological epidemiology of SARS-CoV-2 in tropical African settings by including the following aspects: socio-cultural, economic, and political characteristics as well as the evaluation of measures taken by the different countries to combat the disease is required.en_US
dc.description.sponsorshipACE : Environment and Health CEA-AGIR, Université Cheikh Anta Diopen_US
dc.identifier.citationSevidzem, S. L., Koumba, A. A., Koumba, C. R. Z., Kedote, N. M., Maganga, G. D., Agossou, E. E., ... & Sarr, F. B. (2020). Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2): What Can Africa Learn from Ongoing Research in Epidemiology, Clinical Manifestations, Chemotherapy and Prevention?. Asian Journal of Medicine and Health, 18(6), 17-27.en_US
dc.identifier.uriDOI: 10.9734/AJMAH/2020/v18i630213
dc.publisherAsian Journal of Medicine and Healthen_US
dc.subjectClinical signsen_US
dc.subjectNonvignon Marius Kedoteen_US
dc.subjectGaël Darren Magangaen_US
dc.subjectEssé Elvire Agossouen_US
dc.subjectSafiatou Niaré-Doumboen_US
dc.subjectBitsha-Kitime Dieudoné Kabkiaen_US
dc.subjectLuc Salako Djogbenouen_US
dc.subjectGenevieve Lydie Acapovi-Yaoen_US
dc.subjectIdrissa Sarren_US
dc.subjectJulien Zahouli Bi Zahoulien_US
dc.subjectChimène Nze-Nkoghéen_US
dc.subjectRodrigue Mintsa-Nguemaen_US
dc.subjectAthanase Badoloen_US
dc.subjectEmmanuel Kamba Mebourouen_US
dc.subjectJacques François Mavoungouen_US
dc.subjectFatou Bintou Sarren_US
dc.subjectUniversité Cheikh Anta Diopen_US
dc.titleSevere Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2): What Can Africa Learn from Ongoing Research in Epidemiology, Clinical Manifestations, Chemotherapy and Prevention?en_US
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