Nigerian propolis: chemical composition, antioxidant activity and α-amylase and α-glucosidase inhibition

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dc.contributor.authorAlaribe, Chinwendum Stephenie
dc.contributor.authorEsposito, Tiziana
dc.contributor.authorSansone, Francesca
dc.date.accessioned2023-05-09T10:56:06Z
dc.date.available2023-05-09T10:56:06Z
dc.date.issued2019-11-08
dc.description.abstractPropolis is an attractive natural ingredient to design health products due to its pharmacological effects. Our chemical investigation of a polar extract of Nigerian propolis (NP) led the isolation and identification of five isoflavonoids (1-4, 6), one diarylpropane (5) and one prenylated flavanone (7) by the combination of chromatographic and spectroscopic techniques. Compounds 1, 4 and 7 were found to be the main markers in NP (8.0, 5.0 and 4.0 mg/g of dry extract, respectively). Moreover, NP and its phenolic constituents exhibited in vitro free radical scavenging activity together with a promising antidiabetic effect against α-amylase and α-glucosidase enzymes. Finally, NP showed also a moderate inhibition of Helicobacter pylori growth. These results suggested that NP could be a good candidate in nutraceuticals and food products.en_US
dc.description.sponsorshipACE: Drug Research, Herbal Medicine Development and Regulatory Scienceen_US
dc.identifier.issn1029-2349
dc.identifier.issn1478-6419
dc.identifier.urihttp://hdl.handle.net/123456789/1742
dc.language.isoenen_US
dc.publisherTaylor and Francisen_US
dc.relation.ispartofseriesNatural Product Research;Volume 35, 2021 - Issue 18
dc.subjectα-amylase and α-glucosidase enzymesen_US
dc.subjectNigerian propolisen_US
dc.subjectpolyphenols free-radical scavenging activityen_US
dc.subjectHelicobacter pylorien_US
dc.subjectUniversité de Ouagaen_US
dc.subjectACEDHARSen_US
dc.subjectACE: Drug Research, Herbal Medicine Development and Regulatory Scienceen_US
dc.titleNigerian propolis: chemical composition, antioxidant activity and α-amylase and α-glucosidase inhibitionen_US
dc.typeArticleen_US
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