The Current State of Parkinsonism in West Africa: A Systematic Review

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dc.contributor.authorQuarshie, Jude T. Q
dc.contributor.authorMensah, Esther N.
dc.contributor.authorQuaye, Osbourne
dc.date.accessioned2023-04-22T14:17:03Z
dc.date.available2023-04-22T14:17:03Z
dc.date.issued2021-09-30
dc.description.abstractParkinsonism is one of the most common neurodegenerative diseases among the elderly. Africa is experiencing an increasing burden of age-related conditions including parkinsonism. However, there is not enough data on the prevalence, symptoms, and management of the disorder in West African patients. This systematic review examines the current state of parkinsonism in West Africa by discussing its epidemiology, symptomatology, and treatment. We searched PubMed, BioMed Central, and AJOL databases from January 2000 to December 2020 for studies on parkinsonism conducted in West African countries. We included 32 studies in this review: 23 from Nigeria, 5 from Ghana, and 1 each from Benin, Mali, Niger, and Senegal. Out of the 32 reviewed studies, 11 focused on the prevalence of parkinsonism, 4 examined the genetics of Parkinson’s disease (PD), and 17 described the symptomatology and therapy of parkinsonism. The prevalence of parkinsonism in West Africa ranges from 6.0% to 8.3% of neurologic admissions/consultations. The estimated crude prevalence of PD in West Africa varies from 15 to 572 per 100,000 people. Thus far, no pathogenic genetic variants have been associated with PD in the region. Levodopa is frequently used singly or in combination with other medications to manage parkinsonian symptoms, which is consistent with reports from other African regions. Most of the reviewed studies focused only on PD, limiting assessment of other forms of parkinsonism. Almost all the prevalence studies were hospital-based and monocentric, making it impossible to accurately estimate the true prevalence of parkinsonism in West Africa. Larger community-based prevalence studies are recommended to enable accurate quantification of disease burden. Future genetic investigations should consider a wider array of gene mutations associated with parkinsonism. Moreover, public health surveillance strategies should be established to monitor the epidemiology of the disorderen_US
dc.description.sponsorshipACE: Cell Biology of Infectious and Non-Communicable Diseasesen_US
dc.identifier.citationhttps://doi.org/10.1155/2021/7479423en_US
dc.identifier.issn2090-8083
dc.identifier.issn2042-0080
dc.identifier.urihttp://hdl.handle.net/123456789/1523
dc.language.isoenen_US
dc.publisherHindawien_US
dc.relation.ispartofseriesParkinsons Diseases;vol. 2021
dc.subjectAnastasia R. Aikinsen_US
dc.subjectneurodegenerative diseasesen_US
dc.subjectepidemiologyen_US
dc.subjectdisorderen_US
dc.subjectpathogenic geneticen_US
dc.titleThe Current State of Parkinsonism in West Africa: A Systematic Reviewen_US
dc.typeArticleen_US
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