Prevention of doxorubicin-induced dyslipidaemia, plasma oxidative stress and electrolytes imbalance in Wistar rats by aqueous leaf-extracts of Chromolaena odorata and Tridax procumbens
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Date
2020-11-13
Journal Title
Journal ISSN
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Publisher
Scientific African
Abstract
This study investigated the ability of aqueous leaf-extracts of Chromolaena odorata and
Tridax procumbens to modulate plasma biomarkers of oxidative stress, electrolytes, lipid
profiles and atherogenic indices in doxorubicin treated rats. Doxorubicin was administered at
15 mg/kg body weight (intra-peritioneally, 48 h prior to sacrifice); metformin was
administered daily at 250 mg/kg (orally, for 14 days); while both extracts were daily
administered at 50, 75 and 100 mg/kg (orally, for 14 days). The plasma malondialdehyde,
triglyceride, apolipoprotein B, total cholesterol, non-high density lipoproteins cholesterol,
low density lipoproteins cholesterol and very low density lipoproteins cholesterol, calcium,
chloride and sodium concentrations; atherogenic index of plasma, cardiac risk ratio,
atherogenic coefficient and Castelli’s risk index II of Test control were significantly (p<0.05)
higher than those of all the other groups. However, their plasma ascorbic acid, reduced
glutathione, high density lipoproteins cholesterol, potassium and magnesium concentrations
were significantly (p<0.05) lower than those of all the other groups. In addition, the plasma
catalase and superoxide dismutase activities of Test control were significantly (p<0.05) lower
than those of the others. The above imply that the extracts have the ability to prevent
doxorubicin-induced oxidative stress, dyslipidaemia and electrolytes imbalance. These results
suggest that, at least in part, due to antioxidant and hypolipidaemic properties, aqueous
extracts of T. procumbens and C. odorata leaves may potentially reduce the risk of
doxorubicin-induced cardiovascular disorders
Description
Keywords
dyslipidaemia, atherogenic indices, plasma lipid profiles, doxorubicin;, electrolytes, biomarkers of oxidative stress, Chromolaena odorata, Tridax procumbens, University of Port Harcourt, ACE-PUTOR, ACE: Public Health and Toxicological Research, Nweke Prince C, Okere Ruth, Nwate Tukar L.B
Citation
Mercy O. Ifeanacho , Jude C. Ikewuchi , Catherine C. Ikewuchi , Prince C. Nweke , Ruth Okere , Tukar L.B. Nwate , Prevention of doxorubicin-induced dyslipi daemia, plasma oxidative stress and electrolytes imbalance in Wistar rats by aqueous leaf extracts of Chromolaena odorata and Tridax procumbens, Scientific African (2020), doi: https://doi.org/10.1016/j.sciaf.2020.e00636