Ameliorative effect of Kolaviron, an extract of Garcinia kola seeds, on induced hypertension

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dc.contributor.authorOlatoye, Francis J.
dc.contributor.authorAkindele, Abidemi J.
dc.contributor.authorOnwe, Samson
dc.date.accessioned2023-05-08T11:48:52Z
dc.date.available2023-05-08T11:48:52Z
dc.date.issued2021-05-11
dc.description.abstractObjectives Early diagnosis and management of known cardiovascular disease risk attributes such as hypertension lessens morbidity and mortality as well as increase quality of life of patients. This present study was modelled to investigate the ameliorative effect of Kolaviron, an extract of Garcinia kola Heckel seeds, in ethanol- and sucrose-induced hypertension. Methods Test animals were divided into six groups of six animals each for each hypertensive model. Animals were treated daily with distilled water (10 ml/kg); 35% ethanol (3 g/kg) or sucrose (5–7%); Kolaviron (50, 100 and 200 mg/kg) separately plus ethanol or sucrose and Amlodipine (0.14 mg/kg) separately plus ethanol or sucrose for 8 weeks. Systolic, diastolic and mean arterial pressures were determined using non-invasive BP system after 8 weeks. Blood was obtained for the assessment of biochemical parameters, lipid profile and antioxidant indices. Vital organs were collected for approximation of tissue antioxidant levels. Results Results show that Kolaviron at various doses and Amlodipine significantly reduced (p<0.05–0.001) the elevated systolic, diastolic, and mean arterial pressures produced by ethanol and sucrose administration. Additionally, Kolaviron and Amlodipine significantly overturned (p<0.05–0.001) the reduction in GSH, SOD and CAT, and elevation in MDA levels elicited by ethanol and sucrose. Furthermore, Kolaviron and Amlodipine produced significant reduction (p<0.001) in levels of cholesterol, triglycerides and low-density lipoproteins, as well as significant increase (p<0.01–0.001) in levels of high-density lipoproteins. Conclusions Results from this study demonstrate that Kolaviron possibly possesses significant antihypertensive effect which may possibly be attributed to its antioxidant effects and relative improvement of lipid profile.en_US
dc.description.sponsorshipACE: Drug Research, Herbal Medicine Development and Regulatory Scienceen_US
dc.identifier.citationDOI: 10.1515/jcim-2020-0354en_US
dc.identifier.issn1553-3840
dc.identifier.urihttp://hdl.handle.net/123456789/1724
dc.language.isoenen_US
dc.publisherJ Complement Integr Med .en_US
dc.relation.ispartofseriesJ Complement Integr Med;2021 May 11;19(1)
dc.subjectUniversity of Lagosen_US
dc.subjectACE: Drug Research, Herbal Medicine Development and Regulatory Scienceen_US
dc.subjectACEDHARSen_US
dc.subjectantihypertensiveen_US
dc.subjectantioxidanten_US
dc.subjectcardiovascular diseasesen_US
dc.subjectGarcinia kolaen_US
dc.subjecthypertensionen_US
dc.subjectKolavironen_US
dc.titleAmeliorative effect of Kolaviron, an extract of Garcinia kola seeds, on induced hypertensionen_US
dc.typeArticleen_US
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