A mating-induced reproductive gene promotes Anopheles tolerance to Plasmodium falciparum infection

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dc.contributor.authorMarcenac, Perrine
dc.contributor.authorShaw, W. Robert
dc.contributor.authorKakani, Evdoxia G.
dc.date.accessioned2023-06-09T23:51:52Z
dc.date.available2023-06-09T23:51:52Z
dc.date.issued2020-12-21
dc.description.abstractAnopheles mosquitoes have transmitted Plasmodium parasites for millions of years, yet it remains unclear whether they suffer fitness costs to infection. Here we report that the fecundity of virgin and mated females of two important vectors—Anopheles gambiae and Anopheles stephensi—is not affected by infection with Plasmodium falciparum, demonstrating that these human malaria parasites do not inflict this reproductive cost on their natural mosquito hosts. Additionally, parasite development is not impacted by mating status. However, in field studies using different P. falciparum isolates in Anopheles coluzzii, we find that MatingInduced Stimulator of Oogenesis (MISO), a female reproductive gene strongly induced after mating by the sexual transfer of the steroid hormone 20-hydroxyecdysone (20E), protects females from incurring fecundity costs to infection. MISO-silenced females produce fewer eggs as they become increasingly infected with P. falciparum, while parasite development is not impacted by this gene silencing. Interestingly, previous work had shown that sexual transfer of 20E has specifically evolved in Cellia species of the Anopheles genus, driving the co-adaptation of MISO. Our data therefore suggest that evolution of male-female sexual interactions may have promoted Anopheles tolerance to P. falciparum infection in the Cellia subgenus, which comprises the most important malaria vectors.en_US
dc.description.sponsorshipACE: Bio-technological Innovation for the Elimination of Vector- Borne Diseasesen_US
dc.identifier.citationMarcenac P, Shaw WR, Kakani EG, Mitchell SN, South A, Werling K, et al. (2020) A mating-induced reproductive gene promotes Anopheles tolerance to Plasmodium falciparum infection. PLoS Pathog 16(12): e1008908. https:// doi.org/10.1371/journal.ppat.1008908en_US
dc.identifier.issn1553-7374
dc.identifier.urihttp://hdl.handle.net/123456789/1938
dc.language.isoenen_US
dc.publisherPLoS Pathogen_US
dc.relation.ispartofseriesPLoS Pathog;16(12)
dc.subjectAnopheles gambiaeen_US
dc.subjecteggsen_US
dc.subjectmosquitoesen_US
dc.subjectSara N. Mitchellen_US
dc.subjectAdam Southen_US
dc.subjectCEA-ITECH_MTVen_US
dc.subjectACE: Bio-technological Innovation for the Elimination of Vector- Borne Diseasesen_US
dc.subjectUniversité Nazi Bonien_US
dc.subjectBurkina Fasoen_US
dc.titleA mating-induced reproductive gene promotes Anopheles tolerance to Plasmodium falciparum infectionen_US
dc.typeArticleen_US
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