HIV Viremia Is Associated With APOL1 Variants and Reduced JC-Viruria

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dc.contributor.authorKruzel-Davila, Etty
dc.contributor.authorSankof, Barbara Mensah
dc.contributor.authorAmos-Abanyie, Ernestine Kubi
dc.date.accessioned2023-04-22T14:15:29Z
dc.date.available2023-04-22T14:15:29Z
dc.date.issued2021-08-27
dc.description.abstractVariants in the Apolipoprotein L1 (APOL1) gene (G1-rs60910145, rs73885319, G2-rs71785313) are common in Africans and in individuals of recent African ancestry and are associated with an increased risk of non-diabetic chronic kidney disease (CKD) and in particular of HIV associated nephropathy (HIVAN). In light of the significantly increased risk of HIVAN in carriers of two APOL1 risk alleles, a role in HIV infectivity has been postulated in the mechanism of APOL1 associated kidney disease. Herein, we aim to explore the association between HIV viremia and APOL1 genotype. In addition, we investigated interaction between BK and JC viruria, CKD and HIV viremia. A total of 199 persons living with HIV/AIDS (comprising 82 CKD cases and 117 controls) from among the participants in the ongoing Human Heredity and Health in Africa (H3Africa) Kidney Disease Research Network case control study have been recruited. The two APOL1 renal risk alleles (RRA) genotypes were associated with a higher risk of CKD (OR 12.6, 95% CI 3.89–40.8, p < 0.0001). Even a single APOL1 RRA was associated with CKD risk (OR 4.42, 95% CI 1.49–13.15, p = 0.007). The 2 APOL1 RRA genotypes were associated with an increased probability of having HIV viremia (OR 2.37 95% CI 1.0–5.63, p = 0.05). HIV viremia was associated with increased CKD risk (OR 7.45, 95% CI 1.66–33.35, P = 0.009) and with a significant reduction of JC virus urine shedding (OR 0.35, 95% CI 0.12–0.98, p = 0.046). In contrast to prior studies, JC viruria was not associated with CKD but was restricted in patients with HIV viremia, regardless of CKD status. These findings suggest a role of APOL1 variants in HIV infectivity and emphasize that JC viruria can serve as biomarker for innate immune system activation.en_US
dc.description.sponsorshipACE: Cell Biology of Infectious and Non-Communicable Diseasesen_US
dc.identifier.citationdoi: 10.3389/fmed.2021.718300en_US
dc.identifier.issn2296-858X
dc.identifier.urihttps://datad.aau.org/handle/123456789/1519
dc.language.isoenen_US
dc.publisherFrontiers in Medicineen_US
dc.relation.ispartofseriesFrontiers in Medicine;8:718300
dc.subjectAPOL1en_US
dc.subjectHIV viremiaen_US
dc.subjectJC viruriaen_US
dc.subjectBK viruriaen_US
dc.subjectinnate immuneen_US
dc.subjectkidney diseaseen_US
dc.subjectAnita Ghansahen_US
dc.subjectAlexander Nyarkoen_US
dc.subjectSeth Agyemangen_US
dc.subjectGordon A. Awandareen_US
dc.subjectMoran Szwarcwort-Cohenen_US
dc.subjectAnat Reiner-Benaimen_US
dc.subjectBasem Hijazien_US
dc.subjectIfeoma Ulasien_US
dc.subjectYemi Raheem Rajien_US
dc.subjectVincent Boimaen_US
dc.subjectCharlotte Osafoen_US
dc.subjectVictoria May Adabayerien_US
dc.subjectMichael Matekoleen_US
dc.subjectTimothy O. Olanrewajuen_US
dc.subjectSamuel Ajayien_US
dc.subjectManmak Mamvenen_US
dc.subjectSampson Antwien_US
dc.subjectAdebowale D. Ademolaen_US
dc.subjectJacob Plange-Rhuleen_US
dc.subjectFatiu Arogundadeen_US
dc.subjectPriscilla Abena Akyawen_US
dc.subjectCheryl A. Winkleren_US
dc.subjectBabatunde L. Salakoen_US
dc.subjectAkinlolu Ojoen_US
dc.subjectKarl Skoreckien_US
dc.subjectDwomoa Aduen_US
dc.subjectH3Africa Kidney Disease Research Network Investigatorsen_US
dc.titleHIV Viremia Is Associated With APOL1 Variants and Reduced JC-Viruriaen_US
dc.typeArticleen_US
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