Antioxidant and Anti α-amylase activities of Polar Extracts of Mitracarpus hirtus and Saba Senegalensis and the combination of their Butanolic Extracts

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dc.contributor.authorSarr, Fatou Bintou
dc.contributor.authorSy, Gata Yoro
dc.contributor.authorCabral, Matild
dc.date.accessioned2023-06-10T20:57:43Z
dc.date.available2023-06-10T20:57:43Z
dc.date.issued2023-01-11
dc.descriptionInternational Research Journal of Pure & Applied Chemistry 22(9): 1-8, 2021; Article no.IRJPAC.77260 ISSN: 2231-3443, NLM ID: 101647669en_US
dc.description.abstractDiabetes mellitus is a major public health disease, and it affects all segments of the population around the world. The progression of this disease is worrying, 460 million in 2019, the number of diabetics is estimated in 2045 at 700 million worldwide. The antioxidant and antidiabetic activities of the ethyl acetate (EA) and Butan-1-ol (But-ol) fractions of M hirtus and Saba senegalensis are studied in this work. The results revealed that the fractions possessed flavonoid, tannins, terpenes and sterols; and exhibit potent radical scavenging activity using DPPH as substrate. The butanolic fractions exhibited more significantly α-amylase inhibitory activities than the ethyl acetate fractions. The IC50 values of butanolic fractions are 0.099 and 0.41 mg/ml respectively for M hirtus and S Senegalensis versus 0.44 and 1.45mg/ml ethyl acetate fractions. The combined butanol fractions of the two plants do not lead to the expected synergetic activities. Thus, it could be concluded that due to the presence of antioxidant components in the plant, extracts have well prospective for the management of diabetes and the related condition of oxidative stress.en_US
dc.description.sponsorshipACE : Environment and Health CEA-AGIR, Université Cheikh Anta Diopen_US
dc.identifier.citationSarr, F. B., Sy, G. Y., Cabral, M., Dioum, M. D., Sene, M., Ndong, A., ... & Faye, O. (2021). Antioxidant and Anti α-amylase Activities of Polar Extracts of Mitracarpus hirtus and Saba senegalensis and the Combinason of their Butanolic Extracts. International Research Journal of Pure and Applied Chemistry, 22(9), 1-8.en_US
dc.identifier.issn2231-3443
dc.identifier.urihttp://eparchives.uk/id/eprint/105
dc.identifier.urihttps://doi.org/:10.9734/irjpac/2021/v22i930429
dc.identifier.urihttp://hdl.handle.net/123456789/1953
dc.language.isoenen_US
dc.publisherInternational Research Journal of Pure and Applied Chemistryen_US
dc.subjectDioum, Mbaye Diawen_US
dc.subjectSene, Madieyeen_US
dc.subjectNdong, Awaen_US
dc.subjectSall, Cheikhen_US
dc.subjectFaye, Ousmaneen_US
dc.subjectUniversité Cheikh Anta Diopen_US
dc.subjectSénégalen_US
dc.subjectCEA-AGIRen_US
dc.subjectDiabetesen_US
dc.subjectMitracarpus hirtusen_US
dc.subjectSaba senegalensisen_US
dc.subjectantioxydanten_US
dc.subjectantidiabetesen_US
dc.titleAntioxidant and Anti α-amylase activities of Polar Extracts of Mitracarpus hirtus and Saba Senegalensis and the combination of their Butanolic Extractsen_US
dc.typeArticleen_US
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