Sickle cell disease: A distinction of two most frequent genotypes (HbSS and HbSC)

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dc.contributor.authorda Guarda, Caroline Conceic¸ão
dc.contributor.authorYahoue´de´hou, Sètondji Cocou Modeste Alexandre
dc.contributor.authorSantiago, Rayra Pereira
dc.date.accessioned2023-05-04T07:27:02Z
dc.date.available2023-05-04T07:27:02Z
dc.date.issued2020-01-29
dc.description.abstractSickle cell disease (SCD) consists of a group of hemoglobinopathies in which individuals present highly variable clinical manifestations. Sickle cell anemia (SCA) is the most severe form, while SC hemoglobinopathy (HbSC) is thought to be milder. Thus, we investigated the clinical manifestations and laboratory parameters by comparing each SCD genotype. We designed a cross-sectional study including 126 SCA individuals and 55 HbSC individuals in steady-state. Hematological, biochemical and inflammatory characterization was performed as well as investigation of previous history of clinical events. SCA patients exhibited most prominent anemia, hemolysis, leukocytosis and inflammation, whereas HbSC patients had increased lipid determinations. The main cause of hospitalization was pain crises on both genotypes. Vaso-occlusive events and pain crises were associated with hematological, inflammatory and anemia biomarkers on both groups. Cluster analysis reveals hematologi cal, inflammatory, hemolytic, endothelial dysfunction and anemia biomarkers in HbSC dis ease as well as SCA. The results found herein corroborate with previous studies suggesting that SCA and HbSC, although may be similar from the genetic point of view, exhibit different clinical manifestations and laboratory alterations which are useful to monitor the clinical course of each genotype.en_US
dc.description.sponsorshipACE: Neglected Tropical Diseases and Forensic Biotechnologyen_US
dc.identifier.citationda Guarda CC, Yahoue´de´hou SCMA, Santiago RP, Neres JSdS, Fernandes CFdL, Aleluia MM, et al. (2020) Sickle cell disease: A distinction of two most frequent genotypes (HbSS and HbSC). PLoS ONE 15(1): e0228399. https://doi.org/ 10.1371/journal.pone.0228399en_US
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/123456789/1698
dc.language.isoenen_US
dc.publisherPLoS ONEen_US
dc.relation.ispartofseriesPLoS ONE;
dc.subjectJoelma Santana dos Santos Neresen_US
dc.subjectAhmadu Bello Universityen_US
dc.subjectACENTDFBen_US
dc.subjectSickle cell anemiaen_US
dc.subjecthemolysisen_US
dc.subjectleukocytosisen_US
dc.titleSickle cell disease: A distinction of two most frequent genotypes (HbSS and HbSC)en_US
dc.typeArticleen_US
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