Attenuation of doxorubicin-induced cardiotoxicity in Wistar rats by aqueous leaf-extracts of Chromolaena odorata and Tridax procumbens

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dc.contributor.authorIkewuchi, Jude C.
dc.contributor.authorIkewuchi, Catherine C
dc.contributor.authorIfeanacho, Mercy O.
dc.date.accessioned2023-05-15T11:52:36Z
dc.date.available2023-05-15T11:52:36Z
dc.date.issued2021-03-04
dc.description.abstractThis study investigated the potential protective role of aqueous leaf-extracts of Chromolaena odorata and Tridax procumbens against cardiotoxicity induced by doxorubicin. Materials and methods To this end, their impact on plasma markers of cardiac integrity, cardiac markers of oxidative stress, cardiac lipids and electrolyte profiles, and activities of cardiac ATPases, lactate dehydrogenase and creatine kinase, were monitored in doxorubicin treated rats. Metformin (250 mg/kg body weight, orally) and both extracts (50, 75 and 100 mg/kg, orally) were daily administered for 14 days; while cardiotoxicity was induced with doxorubicin (15 mg/kg, intra-peritioneally, once on the 12th day of study). Results The plasma activities of creatine kinase, lactate dehydrogenase and AST of Test control were significantly (p < 0.05) higher than those of the other groups. Also, the cardiac malondialdehyde, calcium, chloride, sodium, cholesterol and triglyceride concentrations of Test control were significantly (p < 0.05) higher than those of the others. However, the cardiac concentrations of ascorbic acid, reduced glutathione, magnesium and potassium, and cardiac activities of catalase, glutathione peroxidase, superoxide dismutase, Ca2+-ATPase, Mg2+-ATPase, Na+,K+-ATPase, creatine kinase and lactate dehydrogenase of Test control were significantly (p < 0.05) lower than those of the others. Conclusions Pre-treatment with the extracts and metformin elicited a cardioprotective effect, as indicated by the prevention of doxorubicin-induced cardiac oxidative stress and prevention of adverse alterations in plasma cardiac markers, cardiac lipids and electrolyte profiles, as well as improvement of the activities of cardiac ATPases, creatine kinase and lactate dehydrogenase.en_US
dc.description.sponsorshipACE: Public Health and Toxicological Researchen_US
dc.identifier.issn0378-8741
dc.identifier.urihttp://hdl.handle.net/123456789/1776
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofseriesJournal of Ethnopharmacology;274
dc.subjectCardiac ATPasesen_US
dc.subjectCardiac electrolytesen_US
dc.subjectCardiac lipidsen_US
dc.subjectDoxorubicinen_US
dc.subjectPlasma cardiac markersen_US
dc.subjectCardiac oxidative stressen_US
dc.subjectChromolaena odorataen_US
dc.subjectACE-PUTORen_US
dc.subjectACE: Public Health and Toxicological Researchen_US
dc.subjectUniversity of Port Harcourten_US
dc.subjectNigeriaen_US
dc.subjectVictoria S. Jajaen_US
dc.subjectEsther C. Okezueen_US
dc.titleAttenuation of doxorubicin-induced cardiotoxicity in Wistar rats by aqueous leaf-extracts of Chromolaena odorata and Tridax procumbensen_US
dc.typeArticleen_US
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