Alterations in Lipid Profile and Indices of Atherogenicity among Infertile Women Seeking Conception by Assisted Reproductive Technology
Loading...
Date
2020-09-20
Journal Title
Journal ISSN
Volume Title
Publisher
Jornal of Infertility Reproductive Biology
Abstract
Female infertility is common all over the world and lipid disorders are suggested to play a role. This study aimed to evaluate the plasma lipid profile and indices of atherogenicity among infertile women attending assisted reproductive technology clinics. Serum lipid profile (total cholesterol, triglycerides, low- density lipoprotein cholesterol, high- density lipoprotein cholesterol, and calculated indices of atherogenicity were determined in 140 infertile women and 50 healthy age-matched women of proven fertility. The lipid profile was assayed by the spectrophotometric method using reagents supplied by Randox Laboratories, Crumlin, Antrim, UK. The means values of measured parameters were compared between cases and controls by unpaired Students-test. The results showed that age (p<0.001), total cholesterol, triglycerides, low-density lipoprotein, AIP, some cardiac risk ratios, and atherogenic coefficients were significantly higher (p<0.001) while high-density cholesterol was significantly lower (p<0.001) among infertile women than control subjects. The difference in the mean body mass index between the cases and controls was not significant. The calculated indices of atherogenicity except high density/low-density ratio were significantly higher among infertile women seeking assisted reproductive technology for conception than control subjects. The higher indices of atherogenicity among this group of subjects might predispose them to cardiovascular diseases. Therefore, routine evaluation of lipid profile and indices of atherogenicity is suggested.
Description
Keywords
Female, Fertilization, Infertility, Lipids, Reproductive techniques, ACE: Reproductive Health Innovation, CERHI, University of Benin