Renal impairment assessment on adults living nearby a landfill: Early kidney dysfunction biomarkers linked to the environmental exposure to heavy metals

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dc.contributor.authorCabral, Mathilde
dc.contributor.authorGarçon, Guillaume
dc.contributor.authorTouré, Aminata
dc.date.accessioned2023-05-20T21:05:24Z
dc.date.available2023-05-20T21:05:24Z
dc.date.issued2021-02-18
dc.descriptionToxicology Reports, 8, 386-394.en_US
dc.description.abstractThe aim of this study was to assess the integrity and kidney overall functional capacity of subjects exposed to landfill emissions. Urine and blood levels of Pb and Cd, and several of the newly biomarkers of nephrotoxicity (Kim Injury Molecule 1 (KIM-1), alpha-1 Microglobulin (α1 M), beta-2 Microglobulin (β2 M), Cystatin-C (Cyst C), Clusterin, alpha-glutathione S-transferase (GSTα), pi-glutathione S-transferase (GSTπ), Tissue Inhibitor of Metalloproteinase-1 (TIMP1), Calbindin, Neutrophil Gelatinase-Associated Lipocalin (NGAL), Osteopontin (OPN), (Retinol Binding Protein(RBP), Liver-type Fatty Acid-Binding Protein (FABP-1), Trefoil Factor 3 (TFF3), Collagen VI) were measured in order to assess glomerular and tubule damage in adults living near a landfill. Our results indicate glomerular dysfunction in exposed subjects, and supported evidence of necrosis of proximal and distal tubule epithelial cells as specific biomarkers began to appear in the urine. Positive correlation by Pearson test were obtained between : blood Pb and B-OPN, B-Cyst C, Calbindin, U-KIM-1, TIMP1, U-OPN, and U-Clusterin; and also, between urinary Cd and TIMP1, B-Clusterin, U-OPN, FABP-1, Albumin, and U-Clusterin. The relation between biomarkers of Cd/Pb exposure and early effect biomarkers in this study clearly predicts the future risk of severe kidney injury in subjects living close to the landfill.en_US
dc.description.sponsorshipACEImpact: Environment and Health, CEA-AGIRen_US
dc.identifier.citationCabral, M., Garçon, G., Touré, A., Bah, F., Dewaele, D., Bouhsina, S., ... & Verdin, A. (2021). Renal impairment assessment on adults living nearby a landfill: early kidney dysfunction biomarkers linked to the environmental exposure to heavy metals. Toxicology Reports, 8, 386-394.en_US
dc.identifier.urihttps://doi.org/10.1016/j.toxrep.2021.02.009
dc.identifier.urihttp://hdl.handle.net/123456789/1813
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.subjectFatoumata Bahen_US
dc.subjectDorothée Dewaeleen_US
dc.subjectSaâd Bouhsinaen_US
dc.subjectFabrice Cazieren_US
dc.subjectAdama Fayeen_US
dc.subjectMamadou Fallen_US
dc.subjectDominique Courcoten_US
dc.subjectAnthony Verdinen_US
dc.subjectBiomarkersen_US
dc.subjectCadmiumen_US
dc.subjectLandfilen_US
dc.subjectLeaden_US
dc.subjectPopulationen_US
dc.subjectNephrotoxicityen_US
dc.subjectUniversity Cheikh Anta Diopen_US
dc.subjectSenegalen_US
dc.subjectCEA-AGIRen_US
dc.titleRenal impairment assessment on adults living nearby a landfill: Early kidney dysfunction biomarkers linked to the environmental exposure to heavy metalsen_US
dc.typeArticleen_US
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