Multihost Transmission of Schistosoma mansoni in Senegal, 2015–2018
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Date
2020-06-06
Journal Title
Journal ISSN
Volume Title
Publisher
RESEARCH
Abstract
In West Africa, Schistosoma spp. are capable of infecting
multiple definitive hosts, a lifecycle feature that may
complicate schistosomiasis control. We characterized
the evolutionary relationships among multiple Schistosoma
mansoni isolates collected from snails (intermediate
hosts), humans (definitive hosts), and rodents (definitive
hosts) in Senegal. On a local scale, diagnosis of S. mansoni
infection ranged 3.8%–44.8% in school-aged children,
1.7%–52.6% in Mastomys huberti mice, and 1.8%–
7.1% in Biomphalaria pfeifferi snails. Our phylogenetic
framework confirmed the presence of multiple S. mansoni
lineages that could infect both humans and rodents;
divergence times of these lineages varied (0.13–0.02 million
years ago). We propose that extensive movement
of persons across West Africa might have contributed to
the establishment of these various multihost S. mansoni
clades. High S. mansoni prevalence in rodents at transmission
sites frequented by humans further highlights the
implications that alternative hosts could have on future
public health interventions.
Description
Emerging infectious diseases, 26(6), 1234.
Keywords
Anna Borlase, Samba D. Diop, Duncan Berger, Bonnie L. Webster, Babacar Faye, Nicolas D. Diouf, David Rollinson, Mariama Sène, Khalilou Bâ, Joanne P. Webster, University Cheikh Anta Diop, Senegal, CEA-AGIR
Citation
Catalano, S., Léger, E., Fall, C. B., Borlase, A., Diop, S. D., Berger, D., ... & Webster, J. P. (2020). Multihost transmission of Schistosoma mansoni in Senegal, 2015–2018. Emerging infectious diseases, 26(6), 1234.