Plasmodium infection induces cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein

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dc.contributor.authorLapidus, Sarah
dc.contributor.authorLiu, Feimei
dc.contributor.authorCasanovas-Massana, Arnau
dc.date.accessioned2023-06-09T18:23:52Z
dc.date.available2023-06-09T18:23:52Z
dc.date.issued2021
dc.description.abstractIndividuals with acute malaria infection generated high levels of antibodies that cross-react with the SARS-CoV-2 Spike protein. Cross-reactive antibodies specifically recognized the sialic acid moiety on N-linked glycans of the Spike protein and do not neutralize in vitro SARS-CoV-2. Sero-surveillance is critical for monitoring and projecting disease burden and risk during the pandemic; however, routine use of Spike protein-based assays may overestimate SARS-CoV-2 exposure and population-level immunity in malaria-endemic countriesen_US
dc.description.sponsorshipACE: Bio-technological Innovation for the Elimination of Vector- Borne Diseasesen_US
dc.identifier.issn2475-9066
dc.identifier.urihttp://hdl.handle.net/123456789/1936
dc.language.isoenen_US
dc.publishermedRxiven_US
dc.relation.ispartofseriesmedRxiv;
dc.subjectYile Daen_US
dc.subjectJohn D. Hucen_US
dc.subjectCarolina Lucasen_US
dc.subjectPlasmodiumen_US
dc.subjectACE: Bio-technological Innovation for the Elimination of Vector- Borne Diseasesen_US
dc.subjectUniversité Nazi Bonien_US
dc.subjectCEA-ITECH_MTVen_US
dc.titlePlasmodium infection induces cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike proteinen_US
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