Chrysin alleviates alteration of bone-remodeling markers in ovariectomized rats and exhibits estrogen-like activity in silico

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dc.contributor.authorIbrahim, Sadiyat O.
dc.contributor.authorMada, Sanusi B.
dc.contributor.authorAbarshi, Musa M
dc.date.accessioned2023-04-28T17:27:00Z
dc.date.available2023-04-28T17:27:00Z
dc.date.issued2021-07-21
dc.description.abstractBackground: Evidences are beginning to accrue that flavonoids, particularly phytoestrogens, could have beneficial effects against several age-related diseases linked to estrogen deficiency including postmenopausal osteoporosis. Methods: In this study, the effect of chrysin on selected bone-remodeling markers in ovariectomized rats and its estrogen like activity in silico were investigated. Results: The data indicated that administration of chrysin at 50 mg/kg and 100 mg/kg for 6 weeks to OVX rats significantly (p <0.05) prevented body weight gain and partially reverse uterine weight loss. In addition, treatment of OVX rats significantly (p <0.01) increased femur dry weight, femur ash weight, bone ash calcium, and phosphorous levels in a dose-dependent manner. However, there was significant (p < 0.001) decline in serum estradiol level in all OVX rats compared to the sham-operated group. Interestingly, administration of chrysin significantly (p < 0.05) reversed the reduction of estradiol induced by ovariectomy compared to untreated OVX rats. Moreover, administration of chrysin to OVX rats significantly (p < 0.05) suppressed excessive elevation of bone-remodeling markers expression compared to untreated OVX rats. Similarly, molecular docking analysis revealed that chrysin interacts with both α and β estrogen receptors with exothermic binding energies of 229.83 kcal/Mol and 252.72 kcal/Mol, respectively, and also fits perfectly into the active site of both α and β estrogen receptors. Conclusion: This study demonstrated that chrysin exhibits potential antiosteoporotic effects against bone loss in OVX rats through enhanced bone mineral contents and preventing excessive elevation of bone-remodeling markers and bone-resorbing cytokineen_US
dc.description.sponsorshipACE: Neglected Tropical Diseases and Forensic Biotechnologyen_US
dc.identifier.citationIbrahim SO, Mada SB, Abarshi MM, Tanko MS, Babangida S. Chrysin alleviates alteration of bone-remodeling markers in ovariectomized rats and exhibits estrogen-like activity in silico. Hum Exp Toxicol. 2021 Dec;40(12_suppl):S125-S136. doi: 10.1177/09603271211033777. Epub 2021 Jul 21. PMID: 34289748.en_US
dc.identifier.issn0960-3271
dc.identifier.urihttp://hdl.handle.net/123456789/1626
dc.language.isoenen_US
dc.publisherSageen_US
dc.relation.ispartofseriesHuman and Experimental Toxicology;2021, Vol. 40(12S)
dc.subjectChrysinen_US
dc.subjectovariectomized ratsen_US
dc.subjectestradiolen_US
dc.subjectbone-remodeling markersen_US
dc.subjectestrogen receptorsen_US
dc.subjectAhmadu Bello Universityen_US
dc.subjectACENTDFBen_US
dc.titleChrysin alleviates alteration of bone-remodeling markers in ovariectomized rats and exhibits estrogen-like activity in silicoen_US
dc.typeArticleen_US
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