Characterization and Outcomes of Hospitalized Children With Coronavirus Disease 2019: A Report From a Multicenter, Viral Infection and Respiratory Illness Universal Study (Coronavirus Disease 2019) Registry

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dc.contributor.authorBhalala, Utpal S.
dc.contributor.authorGist, Katja M.
dc.contributor.authorTripathi, Sandeep
dc.date.accessioned2023-05-09T19:15:10Z
dc.date.available2023-05-09T19:15:10Z
dc.date.issued2022
dc.description.abstractOBJECTIVES: Multicenter data on the characteristics and outcomes of children hospitalized with coronavirus disease 2019 are limited. Our objective was to describe the characteristics, ICU admissions, and outcomes among children hospitalized with coronavirus disease 2019 using Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study: Coronavirus Disease 2019 registry. DESIGN: Retrospective study. SETTING: Society of Critical Care Medicine Viral Infection and Respiratory Illness Universal Study (Coronavirus Disease 2019) registry. PATIENTS: Children (< 18 yr) hospitalized with coronavirus disease 2019 at participating hospitals from February 2020 to January 2021. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The primary outcome was ICU ad mission. Secondary outcomes included hospital and ICU duration of stay and ICU, hospital, and 28-day mortality. A total of 874 children with coronavirus disease 2019 were reported to Viral Infection and Respiratory Illness Universal Study registry from 51 participating centers, majority in the United States. Median age was 8 years (interquartile range, 1.25–14 yr) with a male:female ratio of 1:2. A majority were non-Hispanic (492/874; 62.9%). Median body mass index (n = 817) was 19.4kg/m2 (16–25.8kg/m2), with 110 (13.4%) overweight and 300 (36.6%) obese. A majority (67%) presented with fever, and 43.2% had comorbidities. A total of 238 of 838 (28.2%) met the Centers for Disease Control and Prevention criteria for multisystem inflammatory syndrome in children, and 404 of 874 (46.2%) were admitted to the ICU. In multivariate logistic regression, age, fever, multisystem inflammatory syndrome in children, and pre-existing seizure disorder were independently associated with a greater odds of ICU admission. Hospital mortality was 16 of 874 (1.8%). Median (interquartile range) duration of ICU (n = 379) and hospital (n = 857) stay were 3.9 days (2–7.7 d) and 4 days (1.9–7.5 d), respectively. For patients with 28-day data, survival was 679 of 787, 86.3% with 13.4% lost to follow-up, and 0.3% deceased. CONCLUSIONS: In this observational, multicenter registry of children with coronavirus disease 2019, ICU admission was common. Older age, fever, multisystem inflammatory syndrome in children, and seizure disorder were independently associated with ICU admission, and mortality was lower among children than mortality reported in adultsen_US
dc.description.sponsorshipACE: Population Health and Policyen_US
dc.identifier.issn2220-3141
dc.identifier.urihttp://hdl.handle.net/123456789/1756
dc.language.isoenen_US
dc.publisherCritical Care Medicine and Wolters Kluwer Health,en_US
dc.relation.ispartofseriesCritical Care Medicine and Wolters Kluwer Health,;January 2022 • Volume 50 • Number 1
dc.subjectKaren Boman,en_US
dc.subjectVishakha K. Kumaren_US
dc.subjectchildrenen_US
dc.subjectcoronavirus disease 2019en_US
dc.subjectintensive care uniten_US
dc.subjectmultisystem inflammatory syndrome in childrenen_US
dc.subjectoutcomesen_US
dc.subjectsevere acute respiratory syndrome coronavirus 2en_US
dc.subjectBayero University, Kanoen_US
dc.subjectACEPHAPen_US
dc.subjectACE: Population Health and Policyen_US
dc.titleCharacterization and Outcomes of Hospitalized Children With Coronavirus Disease 2019: A Report From a Multicenter, Viral Infection and Respiratory Illness Universal Study (Coronavirus Disease 2019) Registryen_US
dc.typeArticleen_US
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