Multi-site comparison of factors influencing progress of African insecticide testing facilities towards an international Quality Management System certification
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Date
2021-11-15
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PLOS ONE
Abstract
Insecticidal mosquito vector control products are vital components of malaria control pro grammes. Test facilities are key in assessing the effectiveness of vector control products against local mosquito populations, in environments where they will be used. Data from these test facilities must be of a high quality to be accepted by regulatory authorities, including the WHO Prequalification Team for vector control products. In 2013–4, seven insecticide testing facilities across sub-Saharan Africa, with technical and financial support from Innovative Vector Control Consortium (IVCC), began development and implementation of quality management system compliant with the principles of Good Laboratory Practice (GLP) to improve data quality and reliability.
Methods and principle findings
We conducted semi-structured interviews, emails, and video-call interviews with individuals
at five test facilities engaged in the IVCC-supported programme and working towards or
having achieved GLP. We used framework analysis to identify and describe factors affecting
progress towards GLP. We found that eight factors were instrumental in progress, and that
test facilities had varying levels of control over these factors. They had high control over the
training programme, project planning, and senior leadership support; medium control over
infrastructure development, staff structure, and procurement; and low control over funding
the availability and accessibility of relevant expertise. Collaboration with IVCC and other partners was key to overcoming the challenges associated with low and medium control factors.
Conclusion
For partnership and consortia models of research capacity strengthening, test facilities can
use their own internal resources to address identified high-control factors. Project plans
should allow additional time for interaction with external agencies to address medium-control factors, and partners with access to expertise and funding should concentrate their efforts on supporting institutions to address low-control factors. In practice, this includes planning for financial sustainability at the outset, and acting to strengthen national and regional training capacity.
Description
Keywords
insecticide, mosquito vector, Matt Kirby, Sarah Moore, Ben Koudou, Université Nazi Boni, CEA-ITECH_MTV, ACE: Bio-technological Innovation for the Elimination of Vector- Borne Diseases
Citation
Begg S, Wright A, Small G, Kirby M, Moore S, Koudou B, et al. (2021) Multi-site comparison of factors influencing progress of African insecticide testing facilities towards an international Quality Management System certification. PLoS ONE 16(11): e0259849. https:// doi.org/10.1371/journal.pone.0259849