Understanding Pediatric Norovirus Epidemiology: A Decade of Study among Ghanaian Children

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dc.contributor.authorLartey, Belinda L.
dc.contributor.authorQuaye, Osbourne
dc.contributor.authorDamanka, Susan A.
dc.date.accessioned2023-04-26T15:29:02Z
dc.date.available2023-04-26T15:29:02Z
dc.date.issued2020-11-18
dc.description.abstractUnderstanding the epidemiology of human norovirus infection in children within Ghana and the entire sub-Saharan African region, where future norovirus vaccines would have the greatest impact, is essential. We analyzed 1337 diarrheic stool samples collected from children <5 years from January 2008 to December 2017 and found 485 (36.2%) shedding the virus. GII.4 (54.1%), GII.3 (7.7%), GII.6 (5.3%), GII.17 (4.7%), and GII.5 (4.7%) were the most common norovirus genotypes. Although norovirus GII.4 remained the predominant capsid genotype throughout the study period, an increase in GII.6 and GII.3 capsid genotypes was observed in 2013 and 2014, respectively. The severity of clinical illness in children infected with GII.4 norovirus strains was similar to illness caused by non-GII.4 strains. Since the epidemiology of norovirus changes rapidly, establishment of systematic surveillance within sentinel sites across the country would enhance the monitoring of circulating norovirus strains and allow continuous understanding of norovirus infection in Ghana.en_US
dc.description.sponsorshipACE: Cell Biology of Infectious and Non-Communicable Diseasesen_US
dc.identifier.citationLartey, B. L., Quaye, O., Damanka, S. A., Agbemabiese, C. A., Armachie, J., Dennis, F. E., Enweronu-Laryea, C., et al. (2020). Understanding Pediatric Norovirus Epidemiology: A Decade of Study among Ghanaian Children. Viruses, 12(11), 1321. MDPI AG. Retrieved from http://dx.doi.org/10.3390/v12111321en_US
dc.identifier.issn1999-4915
dc.identifier.urihttp://hdl.handle.net/123456789/1584
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofseriesViruses;2020, 12(11)
dc.subjectnorovirusen_US
dc.subjectWACCBIP_NCDSen_US
dc.subjectUniversity of Ghanaen_US
dc.subjectgastroenteritis; onestep RT-PCRen_US
dc.subjectgenogroupen_US
dc.subjectgenotypesen_US
dc.subjectGhanaen_US
dc.subjectChantal A. Agbemabieseen_US
dc.subjectJoseph Armachieen_US
dc.subjectFrancis E. Dennisen_US
dc.titleUnderstanding Pediatric Norovirus Epidemiology: A Decade of Study among Ghanaian Childrenen_US
dc.typeArticleen_US
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