High Systolic Blood Pressure, Anterior Segment Changes and Visual Impairment Independently Predict Sickle Cell Retinopathy

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dc.contributor.authorIdris, Ibrahim M
dc.contributor.authorYusuf, Aminu A.
dc.contributor.authorGwarzo, Dalha H.
dc.date.accessioned2023-06-07T17:37:44Z
dc.date.available2023-06-07T17:37:44Z
dc.date.issued2021-06-22
dc.description.abstractSickle cell disease is often complicated by retinopathy, which can be proliferative or non proliferative. Proliferative sickle cell retinopathy potentially leads to blindness. There is a paucity of data on sickle cell disease-related retinopathy from Africa, where the disease is most prevalent. We aimed to determine the clinical, ophthalmic, and laboratory predictors of sickle cell retinopathy in an African population. We conducted a cross-sectional study of 262 participants, aged 13 years and above, with sickle cell disease. Demographic and clinical data were collected using a structured questionnaire and standard physical examinations. Vitreo-retinal specialists performed eye examinations on all the participants. Hematological and biochemical assessments were conducted using standard methods. A multivariate stepwise forward logistic regression was performed to determine the predictors of retinopathy. The median age of the participants was 20 years (interquartile range: 17–25 years). Most of the participants had a homozygous Hb S (HBB: c.20A>T) genotype (96.9%), with 3.1% who carried a Hb S/Hb C (HBB: c.19G>A) genotype. The prevalence of non proliferative sickle cell retinopathy was 24.4%. Only 1.9% had proliferative sickle cell retinopathy (PSCR). Elevated systolic blood pressure (BP) [odds ratio (OR): 6.85, 95% confidence interval (95% CI): 1.05–44.45, p ¼ 0.059], moderate visual impairment (OR: 5.2, 95% CI: 1.39–19.63, p ¼ 0.015), and anterior segment changes (OR: 2.21, 95% CI: 1.19–4.13, p ¼ 0.012) were independently predictive of retinopathy. This study provides new insight into predictors of retinopathy in sickle cell disease, with implications on early screening and preventionen_US
dc.description.sponsorshipACE: Genetic Medicineen_US
dc.identifier.citationIbrahim M. Idris, Aminu A. Yusuf, Dalha H. Gwarzo, Musbahu S. Kurawa, Abdulsalam Shuaib, Aisha A. Galadanci, Hauwa Ibrahim, Awwal M. Borodo, Yusuf D. Jobbi, Maryam B. Danagundi, Sakinatu B. Borodo, Idris Y. Mohammed, Najibah A. Galadanci & Aisha Kuliya-Gwarzo (2021): High Systolic Blood Pressure, Anterior Segment Changes and Visual Impairment Independently Predict Sickle Cell Retinopathy, Hemoglobin, DOI: 10.1080/03630269.2021.1957927en_US
dc.identifier.urihttp://hdl.handle.net/123456789/1919
dc.language.isoenen_US
dc.relation.ispartofseriesHemoglobin;
dc.subjectOphthalmic changesen_US
dc.subjectpredictorsen_US
dc.subjectsickle cell diseaseen_US
dc.subjectACE: Genetic Medicineen_US
dc.subjectWAGMCen_US
dc.subjectUniversity of Ghanaen_US
dc.subjectMusbahu S. Kurawaen_US
dc.subjectAbdulsalam Shuaiben_US
dc.subjectAisha A. Galadancien_US
dc.titleHigh Systolic Blood Pressure, Anterior Segment Changes and Visual Impairment Independently Predict Sickle Cell Retinopathyen_US
dc.typeArticleen_US
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