Cytotoxic Assessment of Xylopia aethiopica [Dun.] A. on Human Prostate and Breast Cancer Cell Lines
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Date
2021-01-02
Journal Title
Journal ISSN
Volume Title
Publisher
Tropical Journal of Natural Product Research
Abstract
Cancer is associated with the unregulated multiplication of cells in specific parts of the body.
Plant-derived products are employed in the treatment and management of such malignant
tumours. Prostate and breast cancers are the most common forms affecting Nigerians. Our aim is
to investigate the cytotoxic effect of Xylopia aethiopica, a commonly consumed spice in
Nigeria, on selected cancer cell lines. The antiproliferative activity of X. aethiopica ethanol
extract of varying concentrations was assessed on MDA-MB-231, MCF-7, and LNCaP using
MTT assay. A dose-dependent antiproliferative activity was observed. The IC50 for X.
aethiopica on the cell lines were ≤ 4.506 ± 0.07 µg/mL except for MCF-7 at 72 hours, where
18.86 ± 0.20 µg/mL was recorded. The findings from this study indicate the potential
antiproliferative and cytotoxic property of X. aethiopica on human prostate and breast cancer
cell lines
Description
Keywords
Xylopia aethiopica, Cell viability, MDA-MB-231, LNCaP, Medicinal plants, Cancer, Nigeria, Covenant University, Digital Development, ACE: Applied Informatics and Communication