Cytotoxic Assessment of Xylopia aethiopica [Dun.] A. on Human Prostate and Breast Cancer Cell Lines

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dc.contributor.authorIweala, Emeka E. J.
dc.contributor.authorBankole, Eunice O.
dc.contributor.authorIheagwam, Franklyn N.
dc.date.accessioned2023-08-30T16:51:18Z
dc.date.available2023-08-30T16:51:18Z
dc.date.issued2021-01-02
dc.description.abstractCancer is associated with the unregulated multiplication of cells in specific parts of the body. Plant-derived products are employed in the treatment and management of such malignant tumours. Prostate and breast cancers are the most common forms affecting Nigerians. Our aim is to investigate the cytotoxic effect of Xylopia aethiopica, a commonly consumed spice in Nigeria, on selected cancer cell lines. The antiproliferative activity of X. aethiopica ethanol extract of varying concentrations was assessed on MDA-MB-231, MCF-7, and LNCaP using MTT assay. A dose-dependent antiproliferative activity was observed. The IC50 for X. aethiopica on the cell lines were ≤ 4.506 ± 0.07 µg/mL except for MCF-7 at 72 hours, where 18.86 ± 0.20 µg/mL was recorded. The findings from this study indicate the potential antiproliferative and cytotoxic property of X. aethiopica on human prostate and breast cancer cell linesen_US
dc.description.sponsorshipACE: Applied Informatics and Communicationen_US
dc.identifier.issn2616-0684
dc.identifier.issn2616-0692
dc.identifier.urihttp://hdl.handle.net/123456789/2100
dc.language.isoenen_US
dc.publisherTropical Journal of Natural Product Researchen_US
dc.relation.ispartofseriesTropical Journal of Natural Product Research;2020; 4(12)
dc.subjectXylopia aethiopicaen_US
dc.subjectCell viabilityen_US
dc.subjectMDA-MB-231en_US
dc.subjectLNCaPen_US
dc.subjectMedicinal plantsen_US
dc.subjectCanceren_US
dc.subjectNigeriaen_US
dc.subjectCovenant Universityen_US
dc.subjectDigital Developmenten_US
dc.subjectACE: Applied Informatics and Communicationen_US
dc.titleCytotoxic Assessment of Xylopia aethiopica [Dun.] A. on Human Prostate and Breast Cancer Cell Linesen_US
dc.typeArticleen_US
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