High Prevalence of Molecular Markers of Plasmodium falciparum Resistance to Sulphadoxine–Pyrimethamine in Parts of Ghana: A Threat to ITPTp-SP?

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dc.contributor.authorAfutu, Leslie L.
dc.contributor.authorBoampong, Johnson N
dc.contributor.authorQuashie, Neils B.
dc.date.accessioned2023-04-22T17:25:45Z
dc.date.available2023-04-22T17:25:45Z
dc.date.issued2021-01-06
dc.description.abstractMalaria in pregnancy is a huge public health problem as it is the cause of maternal anaemia, still birth, premature delivery, low birth weight among others. To tackle this problem, WHO recommended the administration, during pregnancy, of intermittent preventive treatment with sulphadoxine–pyrimethamine (IPTp-SP). The introduction of this policy is likely to create SP drug pressure which may lead to the emergence of parasite strains resistant to the drug. This study investigated the prevalence of the molecular markers of SP resistance as pointers to potential failure of IPTp-SP among pregnant women attending antenatal clinic, women at the point of baby delivery and out patients department (OPD) attendees. The study was conducted in health facilities located in parts of Ghana. Prevalence of mutations in dhfr and dhps genes of Plasmodium falciparum was determined using the method described by Duraisingh et al. The outcome of the study indicated the presence of high prevalence of strains of P.falciparum with the resistant alleles of the dhfr or dhps genes in the three categories of participants. There was a high prevalence of triple mutations (IRN) in the dhfr gene of P.falciparum isolates: 71.4% in peripheral blood of antenatal attendees; 74.1% in placenta cord blood of delivering mothers and 71.1% in OPD attendees. Quintuple mutations were only found in 2 (0.5%) isolates from OPD attendees. This observation might have occurred due to the increased use of SP for IPTp among others. There is the need for an interventional measure in order to protect pregnant women and their unborn childrenen_US
dc.description.sponsorshipACE: Cell Biology of Infectious and Non-Communicable Diseasesen_US
dc.identifier.citationdoi: 10.1093/tropej/fmaa120en_US
dc.identifier.issn0142-6338
dc.identifier.urihttp://hdl.handle.net/123456789/1544
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofseriesjournal of Tropical Pediatrics;Volume 67Issue 1
dc.subjectSulphadoxine–pyrimethamineen_US
dc.subjectMutationen_US
dc.subjectGenotypeen_US
dc.subjectPrevalenceen_US
dc.subjectPregnancyen_US
dc.subjectPlasmodium falciparumen_US
dc.subjectIntermittent preventive treatmenten_US
dc.subjectWACCBIPen_US
dc.titleHigh Prevalence of Molecular Markers of Plasmodium falciparum Resistance to Sulphadoxine–Pyrimethamine in Parts of Ghana: A Threat to ITPTp-SP?en_US
dc.typeArticleen_US
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