Livestock herding and Fulani ethnicity are a combined risk factor for development of early adverse reactions to antivenom treatment: Findings from a cross-sectional study in Nigeria

Simple item page
dc.contributor.authorMenzies, Stefanie K.
dc.contributor.authorThomas, Aniekan O
dc.contributor.authorTiany, Frank-Leonel
dc.date.accessioned2023-05-10T14:06:15Z
dc.date.available2023-05-10T14:06:15Z
dc.date.issued2021-08-12
dc.description.abstractAdverse reactions to antivenom considerably complicate the clinical management of snakebite envenomed patients because it necessitates a temporary suspension of life-saving antivenom, increases costs and can compromise patient outcomes. This study sought to explore the association between cattle-herding occupation and ethnic group and the occurrence of early adverse reactions to antivenom. Methods This cross-sectional study was conducted between the 25th April and 11th July 2011 at the Kaltungo General Hospital in north east Nigeria. The exposure variable of cattle-herding occupation showed a strong correlation with the ethnic group variable, thus these were combined into a new variable with three categories (Fulani and herder, either Fulani or herder, and neither Fulani nor herder). The outcome variable was the occurrence of early adverse reactions, defined as any new symptoms occurring within 6 hours of antivenom administration. Odds Ratios were estimated using multivariable logistic regression models controlling for potential confounders. Results Among 231 envenomed snakebite victims, the overall incidence of early adverse reactions was 11.9% (95% confidence intervals: 8.0–16.9%). Patients who were Fulani and herders had a higher incidence of early adverse reactions compared to patients who were neither Fulani nor herders (20% vs 5.7%). After adjusting for age and gender, victims who were Fulani and herders were 5.9 times more likely to have an early adverse reaction, compared to victims who were neither Fulani nor herders (95% CI: 1.88–18.59; p = 0.002). Interpretation To the best of our knowledge, this is the first study to provide evidence of higher odds of early adverse reactions among patients from a particular occupation and/or ethnic group. We recommend that snake envenomed patients of Fulani origin be especially closely monitored for adverse reactions, that hospitals receiving these patients be appropriately resourced to manage both envenoming and adverse reactions and that premedication with adrenaline should be considered. Our findings provide an argument for speculation on the influence of immunological or lifestyle-related differences on the occurrence of early adversereactions to antivenom.en_US
dc.description.sponsorshipACE: Population Health and Policyen_US
dc.identifier.citationenzies SK, Thomas AO, Tianyi FL, Abubakar SB, Nasidi A, Durfa N, Patel R, Trelfa A, Lalloo DG, Habib AG, Harrison RA. Livestock herding and Fulani ethnicity are a combined risk factor for development of early adverse reactions to antivenom treatment: Findings from a cross-sectional study in Nigeria. PLoS Negl Trop Dis. 2021 Aug 12;15(8):e0009518. doi: 10.1371/journal.pntd.0009518. PMID: 34383742; PMCID: PMC8384187.en_US
dc.identifier.issn1935-2727
dc.identifier.issn1935-2735
dc.identifier.urihttp://hdl.handle.net/123456789/1758
dc.language.isoenen_US
dc.publisherPLoS ONEen_US
dc.relation.ispartofseriesPLoS Negl Trop Dis.;15(8)
dc.subjectSaidu B. Abubakaren_US
dc.subjectAbdulsalami Nasidi,en_US
dc.subjectACEPHAPen_US
dc.subjectACE: Population Health and Policyen_US
dc.subjectNigeriaen_US
dc.subjectBayero University, Kanoen_US
dc.subjectlife-saving antivenomen_US
dc.subjectcattle-herding occupationen_US
dc.subjectSnakebiteen_US
dc.subjectenvenomingen_US
dc.titleLivestock herding and Fulani ethnicity are a combined risk factor for development of early adverse reactions to antivenom treatment: Findings from a cross-sectional study in Nigeriaen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Livestock herding and Fulani ethnicity are a combined risk factor for development of early adverse reactions to antivenom treatment_ Findings from a cross-sectional study in Nigeria _ PLOS Neglected Tropical Dis.pdf
Size:
340.67 KB
Format:
Adobe Portable Document Format
Description:
Main article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Health