Tonelli, MarcelloTiv, SophannyAnand, Shuchi2023-05-202023-05-202021-10-04Tonelli, M., Tiv, S., Anand, S., Mohan, D., Garcia, G. G., Padilla, J. A. G., ... & Muntner, P. (2021). Diagnostic yield of population-based screening for chronic kidney disease in low-income, middle-income, and high-income countries. JAMA network open, 4(10), e2127396-e2127396.doi:10.1001/jamanetworkopen.2021.27396 Key Pointshttp://hdl.handle.net/123456789/1823JAMA network open, 4(10), e2127396-e2127396.IMPORTANCE Population-based screening for chronic kidney disease (CKD) is sometimes recommended based on the assumption that detecting CKD is associated with beneficial changes in treatment. However, the treatment of CKD is often similar to the treatment of hypertension or diabetes, which commonly coexist with CKD. OBJECTIVE To determine the frequency with which population-based screening for CKD is associated with a change in recommended treatment compared with a strategy of measuring blood pressure and assessing glycemia. DESIGN, SETTING, AND PARTICIPANTS This cohort study was conducted using data obtained from studies that evaluated CKD in population-based samples from China (2007-2010), India (2010-2014), Mexico (2007-2008), Senegal (2012), and the United States (2009-2014), including a total of 126 242 adults screened for CKD. Data were analyzed from January 2020 to March 2021. MAIN OUTCOMES AND MEASURES The primary definition of CKD was estimated glomerular filtration rate less than 60 mL/min/1.73m2. For individuals with CKD, the need for a treatment change was defined as not taking an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker or having blood pressure levels of 140/90mmHg or greater. For individuals with CKD who also had diabetes, the need for a treatment change was also defined as having hemoglobin A1c levels of 8%or greater or fasting glucose levels of 178.4mg/dL (9.9 mmol/L) or greater. Case finding was defined as testing for CKD only in adults with hypertension or diabetes.enDeepa Mohan, PhDGuillermo Garcia Garcia, MDJosé Alfonso Gutiérrez Padilla,MD,MScPHScott Klarenbach, MD, MScGuillermo Navarro Blackaller, MDSidy Seck, MD, MPHJinweiWang, PhDLuxia Zhang, MD, MPHPaul Muntner, PhDUniversity Cheikh Anta DiopSenegalCEA-AGIRArticle