Z.P. Joshua, Z.P.Abarshi, M.M.Sani, I.2023-04-282023-04-282021-09-30https://doi.org/10.1016/j.hnm.2021.2001331530-261Xhttp://hdl.handle.net/123456789/1635Micronutrients deficiency is a major challenge especially in Human Immunodeficiency Virus (HIV) infected patients on antiretroviral therapy (ART). This study investigated the impact of natural micronutrient supplements (Vitamins A, C, and E, Selenium and Zinc) from Carrot-ginger (75:25) blend on the micronutrient status and counts of T CD4 + lymphocytes of HIV-infected patients on ART. Ninety HIV-infected-patients attending Special Treatment Clinic, Kafanchan General Hospital were randomized into three groups of thirty patients each: Group 1 are control group and received ART alone, Group 2 are standard group and received ART + Ready to use commercial micronutrient supplements Registered (SelACE® supplement), while Group 3 are supplement group and received ART + Carrot-ginger blend for a period of 90 days. Vitamins A, C and E, selenium, zinc, CD4+ T-cell counts and Body Mass Index (BMI) were assessed using standard methods at baseline (0 day), 30 days, 60 days and 90 days respectively. The results indicated that patients on carrot-ginger blend and SelACE® supplements had significant (p < 0.05) increase in BMI, CD4+ T-cell counts, serum vitamins A, C, E, selenium and zinc from zero day. However, there was no significant (p > 0.05) difference on patients treated with ART alone when compared to their baseline values. In addition, patients on SelACE® supplement revealed significant (p < 0.05) difference in their mean BMI, CD4+ T-cell counts, serum vitamins A, C, E, Selenium and Zinc when compared to patients on carrot-ginger blend after 90 days. The result further indicated a strong positive relationship (p =0.00) between CD4+ T-cell counts, micronutrients status and BMI after 90 days of micronutrient supplementation. Micronutrients supplementation is important during ART treatment and carrot-ginger blend could be a beneficial adjunct to patients on ART due to its potential towards improving the immune system and strengthened nutritional status in patients with HIV infection.enCD4+ T-cell countsMicronutrientsCarrot-ginger blendHuman immunodeficiency virusAhmadu Bello UniversityACENTDFBACE: Neglected Tropical Diseases and Forensic BiotechnologyArticle