Antihyperlipidemic Effects of Silver Nanoparticles Synthesized from Ventilago maderaspatana Leaf Extract on Streptozotocin-Induced Albino Rats
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Date
2021-07-01
Journal Title
Journal ISSN
Volume Title
Publisher
Trop J Nat Prod Res
Abstract
An abnormally high presence of lipid in human blood is a prelude for the emergence of
cardiovascular complications. In this study, effort was made to elucidate the effect of silver
nanoparticles (AgNPs) produced through the help of Ventilago maderaspatana on the
hyperlipidemic conditions in streptozotocin (STZ)-induced Wistar rats. AgNPs were synthesized
biologically using ethyl acetate leaf extract of V. maderaspatana. The synthesis of AgNPs was
confirmed when the color of the solution turned dark brown following the addition of V.
maderaspatana ethyl acetate leaf extract. To confirm further, UV-Vis spectroscopy analysis was
conducted which gave a peak at 430 nm. The results obtained from the FT-IR studies shows that
the compounds in the plant extract may have influenced the formation of AgNPs. The result
obtained from further characterization showed that the synthesized nanoparticles were spherical
and ranged between 10-50 nm. The XRD study indicates crystal nature of the particles with the
size of 50 nm. After the injection of STZ, the lipid profiles were altered abnormally. This can be
found in group II rats (hyperlipidemic control) which had the highest level of serum total
cholesterol (189.1 ± 0.80 mg/dL), triglyceride (177.9 ± 0.88 mg/dL), VLDL-c (42.5 ± 1.80
mg/dL), and LDL-c (55.2 ± 3.83 mg/dL) with the exception of HDL-c which was found low
(10.4 ± 1.04 mg/dL). However, hyperlipidemic groups treated with AgNPs recorded low levels
of cholesterols. Based on this, it can be concluded that biosynthesized AgNPs could be helpful
in lowering cholesterol level
Description
Keywords
Hyperlipidemia, Cardiovascular diseases, Antihyperlipidemic activity, Ventilago maderaspatana, Silver nanoparticles, Biosynthesis, ACE: Public Health and Toxicological Research, ACE-PUTOR, University of Port Harcourt, Nigeria
Citation
: Karuppannan P, Saravanan K, Egbuna C, Uche CZ, Patrick Iwuanyanwu KC, Khan J. Antihyperlipidemic Effects of Silver Nanoparticles Synthesized from Ventilago maderaspatana Leaf Extract on Streptozotocin-Induced Albino Rats. Trop J Nat Prod Res. 2021; 5(6):1066-1071. doi.org/10.26538/tjnpr/v5i6.14