Antihyperlipidemic Effects of Silver Nanoparticles Synthesized from Ventilago maderaspatana Leaf Extract on Streptozotocin-Induced Albino Rats

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dc.contributor.authorKaruppannan, Periyasamy
dc.contributor.authorSaravanan, Kaliyaperumal
dc.contributor.authorEgbuna, Chukwuebuka
dc.date.accessioned2023-05-17T10:43:46Z
dc.date.available2023-05-17T10:43:46Z
dc.date.issued2021-07-01
dc.description.abstractAn abnormally high presence of lipid in human blood is a prelude for the emergence of cardiovascular complications. In this study, effort was made to elucidate the effect of silver nanoparticles (AgNPs) produced through the help of Ventilago maderaspatana on the hyperlipidemic conditions in streptozotocin (STZ)-induced Wistar rats. AgNPs were synthesized biologically using ethyl acetate leaf extract of V. maderaspatana. The synthesis of AgNPs was confirmed when the color of the solution turned dark brown following the addition of V. maderaspatana ethyl acetate leaf extract. To confirm further, UV-Vis spectroscopy analysis was conducted which gave a peak at 430 nm. The results obtained from the FT-IR studies shows that the compounds in the plant extract may have influenced the formation of AgNPs. The result obtained from further characterization showed that the synthesized nanoparticles were spherical and ranged between 10-50 nm. The XRD study indicates crystal nature of the particles with the size of 50 nm. After the injection of STZ, the lipid profiles were altered abnormally. This can be found in group II rats (hyperlipidemic control) which had the highest level of serum total cholesterol (189.1 ± 0.80 mg/dL), triglyceride (177.9 ± 0.88 mg/dL), VLDL-c (42.5 ± 1.80 mg/dL), and LDL-c (55.2 ± 3.83 mg/dL) with the exception of HDL-c which was found low (10.4 ± 1.04 mg/dL). However, hyperlipidemic groups treated with AgNPs recorded low levels of cholesterols. Based on this, it can be concluded that biosynthesized AgNPs could be helpful in lowering cholesterol levelen_US
dc.description.sponsorshipACE: Public Health and Toxicological Researchen_US
dc.identifier.citation: Karuppannan P, Saravanan K, Egbuna C, Uche CZ, Patrick Iwuanyanwu KC, Khan J. Antihyperlipidemic Effects of Silver Nanoparticles Synthesized from Ventilago maderaspatana Leaf Extract on Streptozotocin-Induced Albino Rats. Trop J Nat Prod Res. 2021; 5(6):1066-1071. doi.org/10.26538/tjnpr/v5i6.14en_US
dc.identifier.issn2616-0684
dc.identifier.issn2616-0692
dc.identifier.urihttp://hdl.handle.net/123456789/1792
dc.language.isoenen_US
dc.publisherTrop J Nat Prod Resen_US
dc.relation.ispartofseriesTrop J Nat Prod Res;, June 2021; 5(6):
dc.subjectHyperlipidemiaen_US
dc.subjectCardiovascular diseasesen_US
dc.subjectAntihyperlipidemic activityen_US
dc.subjectVentilago maderaspatanaen_US
dc.subjectSilver nanoparticlesen_US
dc.subjectBiosynthesisen_US
dc.subjectACE: Public Health and Toxicological Researchen_US
dc.subjectACE-PUTORen_US
dc.subjectUniversity of Port Harcourten_US
dc.subjectNigeriaen_US
dc.titleAntihyperlipidemic Effects of Silver Nanoparticles Synthesized from Ventilago maderaspatana Leaf Extract on Streptozotocin-Induced Albino Ratsen_US
dc.typeArticleen_US
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