Multihost Transmission of Schistosoma mansoni in Senegal, 2015–2018

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In West Africa, Schistosoma spp. are capable of infecting multiple definitive hosts, a lifecycle feature that may complicate schistosomiasis control. We characterized the evolutionary relationships among multiple Schistosoma mansoni isolates collected from snails (intermediate hosts), humans (definitive hosts), and rodents (definitive hosts) in Senegal. On a local scale, diagnosis of S. mansoni infection ranged 3.8%–44.8% in school-aged children, 1.7%–52.6% in Mastomys huberti mice, and 1.8%–7.1% in Biomphalaria pfeifferi snails. Our phylogenetic framework confirmed the presence of multiple S. mansoni lineages that could infect both humans and rodents; divergence times of these lineages varied (0.13–0.02 million years ago). We propose that extensive movement of persons across West Africa might have contributed to the establishment of these various multihost S. mansoni clades. High S. mansoni prevalence in rodents at transmission sites frequented by humans further highlights the implications that alternative hosts could have on future public health interventions.
Emerg Infect Dis. 2020 Jun; 26(6): 1234–1242.
Schistosoma, Schistosoma mansoni, zoonoses, parasites, Rodentia, Rodents, Mastomys huberti, snail, Biomphalaria pfeifferi, children, West Africa, Senegal River Basin, Lac de Guiers, infectious diseases, One Health, molecular epidemiology, reservoir, transmission, definitive host, evolution, multihost system, schistosomiasis, Sénégal, Université Cheikh Anta Diop, CEA-AGIR, Anna Borlase, Samba D. Diop, Duncan Berger, Bonnie L. Webster, Babacar Faye, Nicolas D. Diouf, David Rollinson, Mariama Sène, Khalilou Bâ, Joanne P. Webster
Catalano, S., Léger, E., Fall, C. B., Borlase, A., Diop, S. D., Berger, D., ... & Webster, J. P. (2020). Multihost transmission of Schistosoma mansoni in Senegal, 2015–2018. Emerging infectious diseases, 26(6), 1234.