Multihost Transmission of Schistosoma mansoni in Senegal, 2015–2018

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dc.contributor.authorCatalano, Stefano
dc.contributor.authorLéger, Elsa
dc.contributor.authorFall, Cheikh B.
dc.date.accessioned2023-06-12T16:30:00Z
dc.date.available2023-06-12T16:30:00Z
dc.date.issued2020-06
dc.descriptionEmerg Infect Dis. 2020 Jun; 26(6): 1234–1242.en_US
dc.description.abstractIn West Africa, Schistosoma spp. are capable of infecting multiple definitive hosts, a lifecycle feature that may complicate schistosomiasis control. We characterized the evolutionary relationships among multiple Schistosoma mansoni isolates collected from snails (intermediate hosts), humans (definitive hosts), and rodents (definitive hosts) in Senegal. On a local scale, diagnosis of S. mansoni infection ranged 3.8%–44.8% in school-aged children, 1.7%–52.6% in Mastomys huberti mice, and 1.8%–7.1% in Biomphalaria pfeifferi snails. Our phylogenetic framework confirmed the presence of multiple S. mansoni lineages that could infect both humans and rodents; divergence times of these lineages varied (0.13–0.02 million years ago). We propose that extensive movement of persons across West Africa might have contributed to the establishment of these various multihost S. mansoni clades. High S. mansoni prevalence in rodents at transmission sites frequented by humans further highlights the implications that alternative hosts could have on future public health interventions.en_US
dc.description.sponsorshipACE : Environment and Health, CEA-AGIRen_US
dc.identifier.citationCatalano, S., Léger, E., Fall, C. B., Borlase, A., Diop, S. D., Berger, D., ... & Webster, J. P. (2020). Multihost transmission of Schistosoma mansoni in Senegal, 2015–2018. Emerging infectious diseases, 26(6), 1234.en_US
dc.identifier.uri10.3201/eid2606.200107
dc.identifier.urihttp://hdl.handle.net/123456789/2000
dc.language.isoenen_US
dc.publisherPubMed Centralen_US
dc.subjectSchistosomaen_US
dc.subjectSchistosoma mansonien_US
dc.subjectzoonosesen_US
dc.subjectparasitesen_US
dc.subjectRodentiaen_US
dc.subjectRodentsen_US
dc.subjectMastomys hubertien_US
dc.subjectsnailen_US
dc.subjectBiomphalaria pfeifferien_US
dc.subjectchildrenen_US
dc.subjectWest Africaen_US
dc.subjectSenegal River Basinen_US
dc.subjectLac de Guiersen_US
dc.subjectinfectious diseasesen_US
dc.subjectOne Healthen_US
dc.subjectmolecular epidemiologyen_US
dc.subjectreservoiren_US
dc.subjecttransmissionen_US
dc.subjectdefinitive hosten_US
dc.subjectevolutionen_US
dc.subjectmultihost systemen_US
dc.subjectschistosomiasisen_US
dc.subjectSénégalen_US
dc.subjectUniversité Cheikh Anta Diopen_US
dc.subjectCEA-AGIRen_US
dc.subjectAnna Borlaseen_US
dc.subjectSamba D. Diopen_US
dc.subjectDuncan Bergeren_US
dc.subjectBonnie L. Websteren_US
dc.subjectBabacar Fayeen_US
dc.subjectNicolas D. Dioufen_US
dc.subjectDavid Rollinsonen_US
dc.subjectMariama Sèneen_US
dc.subjectKhalilou Bâen_US
dc.subjectJoanne P. Websteren_US
dc.titleMultihost Transmission of Schistosoma mansoni in Senegal, 2015–2018en_US
dc.typeArticleen_US
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