Phytol suppresses parasitemia and ameliorates anaemia and oxidative brain damage in mice infected with Plasmodium berghei
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Date
2021-03-15
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
The quest for the development of a novel antimalarial drug informed the decision to subject phytol to in vivo
trials following a demonstration of therapeutic potential against chloroquine sensitive strain of Plasmodium
falciparum under in vitro condition. On this basis, the in vivo anti-Plasmodium berghei activity of phytol including
the ameliorative effects of the compound on P. berghei-associated anaemia and organ damage were investigated.
Mice were infected with chloroquine-sensitive strain of P. berghei and were treated with phytol at a dose of 10
and 20 mg/kg body weight (BW) for four days. The levels of parasitemia, packed cell volume and redox sensitive
biomarkers of liver, brain and spleen tissues were determined. Our result revealed that phytol significantly (p <
0.05) suppressed the multiplication of P. berghei in a dose-dependent manner. Additionally, the phytol signifi cantly (p < 0.05) ameliorated the P. berghei-induced anaemia and brain damage. Data from the present study
demonstrated that phytol has suppressive effect on P. berghei and could ameliorate some P. berghei-induced
pathological changes.
Description
Keywords
ACENTDFB, Ahmadu Bello University, Phytol, Anaemia, Oxidative stress, Plasmodium berghei, Abdulmalik Abdullahi Salman
Citation
https://doi.org/10.1016/j.exppara.2021.108097