Phytol suppresses parasitemia and ameliorates anaemia and oxidative brain damage in mice infected with Plasmodium berghei

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dc.contributor.authorUsman, Mohammed Aliyu
dc.contributor.authorUsman, Fadilat Isah
dc.contributor.authorAbubakar, Muhammad Sani
dc.date.accessioned2023-04-29T20:37:29Z
dc.date.available2023-04-29T20:37:29Z
dc.date.issued2021-03-15
dc.description.abstractThe quest for the development of a novel antimalarial drug informed the decision to subject phytol to in vivo trials following a demonstration of therapeutic potential against chloroquine sensitive strain of Plasmodium falciparum under in vitro condition. On this basis, the in vivo anti-Plasmodium berghei activity of phytol including the ameliorative effects of the compound on P. berghei-associated anaemia and organ damage were investigated. Mice were infected with chloroquine-sensitive strain of P. berghei and were treated with phytol at a dose of 10 and 20 mg/kg body weight (BW) for four days. The levels of parasitemia, packed cell volume and redox sensitive biomarkers of liver, brain and spleen tissues were determined. Our result revealed that phytol significantly (p < 0.05) suppressed the multiplication of P. berghei in a dose-dependent manner. Additionally, the phytol signifi cantly (p < 0.05) ameliorated the P. berghei-induced anaemia and brain damage. Data from the present study demonstrated that phytol has suppressive effect on P. berghei and could ameliorate some P. berghei-induced pathological changes.en_US
dc.description.sponsorshipACE: Neglected Tropical Diseases and Forensic Biotechnologyen_US
dc.identifier.citationhttps://doi.org/10.1016/j.exppara.2021.108097en_US
dc.identifier.issn0014-4894
dc.identifier.issn1090-2449
dc.identifier.urihttp://hdl.handle.net/123456789/1648
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesExperimental Parasitology;224 (2021)
dc.subjectACENTDFBen_US
dc.subjectAhmadu Bello Universityen_US
dc.subjectPhytolen_US
dc.subjectAnaemiaen_US
dc.subjectOxidative stressen_US
dc.subjectPlasmodium bergheien_US
dc.subjectAbdulmalik Abdullahi Salmanen_US
dc.titlePhytol suppresses parasitemia and ameliorates anaemia and oxidative brain damage in mice infected with Plasmodium bergheien_US
dc.typeArticleen_US
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