Trends in extrapulmonary TB cases at three teaching hospitals in Ghana, 2008–2017

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dc.contributor.authorAddo, S. O.
dc.contributor.authorMensah, G. I.
dc.contributor.authorMosi, L,
dc.date.accessioned2023-04-22T18:36:57Z
dc.date.available2023-04-22T18:36:57Z
dc.date.issued2021-03-21
dc.description.abstractSETTING: Three teaching hospitals in Ghana. OBJECTIVE: To elucidate trends in demographics, clinical characteristics and treatment outcomes in extrapulmonary TB (EPTB) patients. DESIGN: This was a retrospective study involving the review and comparison of EPTB and pulmonary TB (PTB) data from 1 January 2008 to 31 December 2017 in TB registers and treatment cards. RESULTS: Of 15,392 TB cases, 4607 (30%) were EPTB, including 4477/4607 (97%) new cases. There were 2,679/4607 (58%) males and the age range was 0.3 to 96 years. Pleural TB (1021/4607, 22%) was the most common. Treatment success rates for EPTB and PTB were respectively 72% and 84%. HIV positivity was high among patients with disseminated/miliary TB (429/779, 55%) and TB meningitis (242/526, 46%). To note, disseminated/miliary TB (χ2 = 33.53, P < 0.0001) increased, whereas TB meningitis (χ2 = 19.43, P < 0.0001) decreased over the 10-year period. Mortality among EPTB patients was associated with increasing age (25 years), disseminated/miliary TB, TB meningitis and HIV positivity. CONCLUSIONS: There is male preponderance for both EPTB and PTB in Ghana. Increasing age, disseminated/ miliary TB, TB meningitis and HIV are risk factors for mortality among EPTB patients. This emphasises the need for public education on the risk factors for EPTB and preventive strategiesen_US
dc.description.sponsorshipACE: Cell Biology of Infectious and Non-Communicable Diseasesen_US
dc.identifier.citationdoi: 10.5588/pha.20.0061.en_US
dc.identifier.issn2220-8372
dc.identifier.urihttp://hdl.handle.net/123456789/1548
dc.language.isoenen_US
dc.publisherPublic Health Actioen_US
dc.relation.ispartofseriesPublic Health Actio;VOL 11 no 1
dc.subjectEPTBen_US
dc.subjectTB registeren_US
dc.subjectretrospective studyen_US
dc.subjecttreatment outcomesen_US
dc.subjectWACCBIPen_US
dc.subjectA. Abrahamsen_US
dc.subjectB. Bonfohen_US
dc.subjectR. Kazwalaen_US
dc.subjectJ. Zinsstag,en_US
dc.subjectK. K. Addoen_US
dc.titleTrends in extrapulmonary TB cases at three teaching hospitals in Ghana, 2008–2017en_US
dc.typeArticleen_US
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