Assessment of endothelial function in subjects with obstructive sleep apnea hypopnea syndrome
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Date
2021-08-10
Journal Title
Journal ISSN
Volume Title
Publisher
Academic Journals (Journal of Physiology and Pathophysiology)
Abstract
Obstructive sleep apnea hypopnea syndrome (OSAHS) is characterized by recurrent episodes of
interruption of ventilation responsible for hypoxemia, hypercapnia and hyper activation of the
autonomic nervous system. Hypoxemia followed by re-oxygenation promotes the formation of free
radicals, oxidative stress and vascular inflammation, leading to endothelial dysfunction. The objective
of this cross-sectional study conducted at the laboratory of Physiology of Gaston Berger University of
Saint-Louis was to assess endothelial function during sleep apnea hypopnea syndrome. The
endothelial function was explored non-invasively by Endopat 2000. Free and informed consent was
required. Data analysis was carried out on Epi Info 7, uni-varied and bi-varied analyzes performed with a
significance threshold p <5%. The study involved 42 patients including 69% women and 31% men. The
average age was 52.11±8.31 years with a predominance of the (40-50yrs and 50-60yrs). The most
frequently medical disorder was hypertension with 71.43%. Over 75% of the subjects were obese or
overweight. OSAHS was mild in 35.71% of cases, moderate 38.1% and severe 26.19%. Endothelial
dysfunction was found in 27.5% of the subjects. It was most noted in subjects with severe OSAHS, with
no statistical significant difference. No significant association was found between endothelial
dysfunction, gender, age and body weight. Endothelial function is often impaired during OSAHS.
Studies on a larger sample should be done for more conclusive results.
Description
Journal of Physiology and Pathophysiology, 12(1), 11-16.
Keywords
Endothelial function, sleep apnea hypopnea syndrom, endopat, University Cheikh Anta Diop, Senegal, CEA-AGIR
Citation
Bâ, F., Sar, F. B., & Bâ, A. (2021). Assessment of endothelial function in subjects with obstructive sleep apnea hypopnea syndrome. Journal of Physiology and Pathophysiology, 12(1), 11-16.