Parallels in Sepsis and COVID-19 Conditions: Implications for Managing Severe COVID-19
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Date
2021-02-03
Journal Title
Journal ISSN
Volume Title
Publisher
Front. Immunol
Abstract
Sepsis is a life-threatening systemic illness attributed to a dysregulated host response to
infection. Sepsis is a global burden killing ~11 million persons annually. In December 2019,
a novel pneumonia condition termed coronavirus disease 2019 (COVID-19), caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged and has
resulted in more than 1,535,982 deaths globally as of 8th December 2020. These two
conditions share many pathophysiological and clinical features. Notably, both sepsis and
COVID-19 patients experience consumptive thrombocytopenia, haemolytic anaemia,
vascular microthrombosis, multi-organ dysfunction syndrome, coagulopathy, septic
shock, respiratory failure, fever, leukopenia, hypotension, leukocytosis, high cytokine
production and high predisposition to opportunistic infections. Considering the parallels in
the immunopathogenesis and pathophysiological manifestations of sepsis and COVID 19, it is highly likely that sepsis care, which has a well-established history in most health
systems, could inform on COVID-19 management. In view of this, the present perspective
compares the immunopathogenesis and pathophysiology of COVID-19 and non-SARS CoV-2 induced sepsis, and lessons from sepsis that can be applicable to COVID 19 managem
Description
Keywords
Coronavirus, COVID-19, SARS-CoV-2, sepsis, cytokine storm, immunosuppression,, hypovolemia, Alexandra Lindsey Djomkam Zune, Oloche Owoicho, University of Ghana, WACCBIP_NCDS, Yaw Bediako, Samuel Duodu
Citation
Olwal CO, Nganyewo NN, Tapela K, Djomkam Zune AL, Owoicho O, Bediako Y and Duodu S (2021) Parallels in Sepsis and COVID-19 Conditions: Implications for Managing Severe COVID-19