Parallels in Sepsis and COVID-19 Conditions: Implications for Managing Severe COVID-19

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dc.contributor.authorOlwal, Charles Ochieng
dc.contributor.authorNganyewo, Nora Nghuchuzie
dc.contributor.authorTapela, Kesego
dc.date.accessioned2023-04-24T15:07:54Z
dc.date.available2023-04-24T15:07:54Z
dc.date.issued2021-02-03
dc.description.abstractSepsis is a life-threatening systemic illness attributed to a dysregulated host response to infection. Sepsis is a global burden killing ~11 million persons annually. In December 2019, a novel pneumonia condition termed coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged and has resulted in more than 1,535,982 deaths globally as of 8th December 2020. These two conditions share many pathophysiological and clinical features. Notably, both sepsis and COVID-19 patients experience consumptive thrombocytopenia, haemolytic anaemia, vascular microthrombosis, multi-organ dysfunction syndrome, coagulopathy, septic shock, respiratory failure, fever, leukopenia, hypotension, leukocytosis, high cytokine production and high predisposition to opportunistic infections. Considering the parallels in the immunopathogenesis and pathophysiological manifestations of sepsis and COVID 19, it is highly likely that sepsis care, which has a well-established history in most health systems, could inform on COVID-19 management. In view of this, the present perspective compares the immunopathogenesis and pathophysiology of COVID-19 and non-SARS CoV-2 induced sepsis, and lessons from sepsis that can be applicable to COVID 19 managemen_US
dc.description.sponsorshipACE: Cell Biology of Infectious and Non-Communicable Diseasesen_US
dc.identifier.citationOlwal CO, Nganyewo NN, Tapela K, Djomkam Zune AL, Owoicho O, Bediako Y and Duodu S (2021) Parallels in Sepsis and COVID-19 Conditions: Implications for Managing Severe COVID-19en_US
dc.identifier.issn2296-858X
dc.identifier.urihttp://hdl.handle.net/123456789/1565
dc.language.isoenen_US
dc.publisherFront. Immunolen_US
dc.relation.ispartofseriesFrontiers in Immunology;12
dc.subjectCoronavirusen_US
dc.subjectCOVID-19en_US
dc.subjectSARS-CoV-2en_US
dc.subjectsepsisen_US
dc.subjectcytokine stormen_US
dc.subjectimmunosuppression,en_US
dc.subjecthypovolemiaen_US
dc.subjectAlexandra Lindsey Djomkam Zuneen_US
dc.subjectOloche Owoichoen_US
dc.subjectUniversity of Ghanaen_US
dc.subjectWACCBIP_NCDSen_US
dc.subjectYaw Bediakoen_US
dc.subjectSamuel Duoduen_US
dc.titleParallels in Sepsis and COVID-19 Conditions: Implications for Managing Severe COVID-19en_US
dc.typeArticleen_US
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