Activity of Compounds from Temperate Propolis against Trypanosoma brucei and Leishmania mexicana

Simple item page
dc.contributor.authorAlotaibi, Adullah
dc.contributor.authorEbiloma, Godwin U.
dc.contributor.authorWilliams, Roderick
dc.date.accessioned2023-04-26T16:57:34Z
dc.date.available2023-04-26T16:57:34Z
dc.date.issued2021-06-26
dc.descriptionJournals of Molecules Vol 26 (3)en_US
dc.description.abstractEthanolic extracts of samples of temperate zone propolis, four from the UK and one from Poland, were tested against three Trypanosoma brucei strains and displayed EC50 values < 20 g/mL. The extracts were fractionated, from which 12 compounds and one two-component mixture were isolated, and characterized by NMR and high-resolution mass spectrometry, as 3-acetoxypinobanksin, tectochrysin, kaempferol, pinocembrin, 40-methoxykaempferol, galangin, chrysin, apigenin, pinostrobin, cinnamic acid, coumaric acid, cinnamyl ester/coumaric acid benzyl ester (mixture), 40,7- dimethoxykaempferol, and naringenin 40,7-dimethyl ether. The isolated compounds were tested against drug-sensitive and drug-resistant strains of T. brucei and Leishmania mexicana, with the highest activities 15 M. The most active compounds against T. brucei were naringenin 40,7 dimethyl ether and 40methoxy kaempferol with activity of 15–20 M against the three T. brucei strains. The most active compounds against L. mexicana were 40,7-dimethoxykaempferol and the coumaric acid ester mixture, with EC50 values of 12.9 3.7 M and 13.1 1.0 M. No loss of activity was found with the diamidine- and arsenical-resistant or phenanthridine-resistant T. brucei strains, or the miltefosineresistant L. mexicana strain; no clear structure activity relationship was observed for the isolated compounds. Temperate propolis yields multiple compounds with anti-kinetoplastid activity.en_US
dc.description.sponsorshipMDPIen_US
dc.identifier.citationAlotaibi, A., Ebiloma, G. U., Williams, R., Alfayez, I. A., Natto, M. J., Alenezi, S., ... & Watson, D. G. (2021). Activity of Compounds from Temperate Propolis against Trypanosoma brucei and Leishmania mexicana. Molecules, 26(13), 3912.en_US
dc.identifier.issn1420-3049
dc.identifier.urihttps://datad.aau.org/handle/123456789/1606
dc.identifier.urihttps://doi.org/10.3390/molecules26133912en
dc.language.isoEnglishen_US
dc.publisherMDPIen_US
dc.subjecttemperate propolisen_US
dc.subjectflavonoidsen_US
dc.subjectisolated compoundsen_US
dc.subjectTrypanosoma bruceien_US
dc.subjectLeishmania mexicanaen_US
dc.subjectIbrahim A. Alfayezen_US
dc.subjectManal J. Nattoen_US
dc.subjectSameah Alenezien_US
dc.subjectWeam Siherien_US
dc.subjectMalik AlQarnien_US
dc.subjectJohn O. Igolien_US
dc.subjectJames Fearnleyen_US
dc.subjectHarry P. De Koningen_US
dc.subjectDavid G. Watsonen_US
dc.subjectBenue State Universityen_US
dc.subjectNigeriaen_US
dc.subjectCEFTERen_US
dc.titleActivity of Compounds from Temperate Propolis against Trypanosoma brucei and Leishmania mexicanaen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Activity of Compounds from Temperate Propolis.pdf
Size:
327.35 KB
Format:
Adobe Portable Document Format
Description:
Main article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Agriculture